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Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues

机译：胰腺癌组织和邻近非癌组织中乙型肝炎病毒DNA和抗原的鉴定及其影响

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摘要

Increasing evidence suggests that a link exists between hepatitis B virus (HBV) serum markers and pancreatic cancer (PC). In this study, HBsAg and HBcAg were expressed in 21.0% (34/162) of PC and 29.0% (47/162) of non-tumor pancreatic tissues, and they were significantly associated with chronic pancreatitis (. P=. 0.000). The HBV S, C and X genes were identified in 20% (6/30) of PC and 26.9% (7/26) of non-tumor tissues by PCR. A serological survey revealed that the prevalence of HBV DNA and anti-HBc was significantly increased in PC patients compared with healthy controls. Our data suggest that HBV infection in the pancreas may play an etiologic role in PC.
机译：越来越多的证据表明，乙型肝炎病毒（HBV）血清标志物与胰腺癌（PC）之间存在联系。在这项研究中，HBsAg和HBcAg在21.0％（34/162）的PC和29.0％（47/162）的非肿瘤胰腺组织中表达，它们与慢性胰腺炎显着相关（。P =。0.000）。通过PCR在20％（6/30）的PC和26.9％（7/26）的非肿瘤组织中鉴定出HBV S，C和X基因。一项血清学调查显示，与健康对照组相比，PC患者的HBV DNA和抗HBc患病率显着增加。我们的数据表明，胰腺中的HBV感染可能在PC中起病因作用。

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