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Severe fatigue during the palliative treatment phase of cancer: An exploratory Study

机译:癌症姑息治疗阶段的严重疲劳:一项探索性研究

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Because of a rise in incidence and more effective treatments, the prevalence of patients with metastatic cancer is increasing fast. When palliative treatment is aimed at maintaining or improving patients' quality of life, knowledge about severe fatigue is clinically relevant because of its debilitating effect, but at present this information is lacking. OBJECTIVE:: This study investigated the prevalence of severe fatigue in patients with various incurable cancers and whether severe fatigue increased with further treatment lines and differed between various cancers and treatment modalities. In addition, a relationship between severe fatigue and other symptoms was examined. METHODS:: Patients were asked to fill in the Checklist Individual Strength, European Organization of Research and Treatment of Cancer-Quality of Life Questionnaire C30, and the McGill Pain Questionnaire during palliative anticancer treatment, and hemoglobin levels were collected. RESULTS:: Of all participating patients (n = 137), 47% were severely fatigued. Patients who received first line of treatment were significantly less often severely fatigued (40%) compared with patients who received further lines (60%). Significantly more severe fatigue was observed when patients had more pain, dyspnea, appetite loss, nausea, vomiting, and constipation. CONCLUSIONS:: During the phase of palliative anticancer treatment, fatigue was the most common symptom, nearly half of the patients had severe fatigue increasing with further treatment lines. Various treatment-related symptoms were related to more severe fatigue. IMPLICATIONS FOR PRACTICE:: As severe fatigue is significantly related to other symptoms of cancer and its treatment, the screening and treatment of these cancer-related symptoms should be more stringent, as they might negatively influence each other.
机译:由于发病率的提高和更有效的治疗方法,转移性癌症患者的患病率迅速增加。当姑息治疗旨在维持或改善患者的生活质量时,关于严重疲劳的知识由于其使人衰弱的作用而在临床上具有相关性,但目前尚缺乏此信息。目的:本研究调查了各种不可治愈的癌症患者中严重疲劳的患病率,以及严重疲劳是否随着进一步的治疗线而增加以及在各种癌症和治疗方式之间是否有所不同。另外,检查了严重疲劳与其他症状之间的关系。方法:要求患者在姑息抗癌治疗期间填写个人强度检查清单,欧洲研究和治疗癌症质量生活质量调查表组织C30和麦吉尔疼痛调查表,并收集血红蛋白水平。结果:在所有参与的患者(n = 137)中,有47%严重疲劳。与接受其他一线治疗的患者(60%)相比,接受一线治疗的患者的严重疲劳程度(40%)明显更少。当患者出现更多的疼痛,呼吸困难,食欲不振,恶心,呕吐和便秘时,就会出现严重的疲劳。结论:在姑息性抗癌治疗阶段,疲劳是最常见的症状,近一半的患者随着进一步的治疗而出现严重的疲劳。各种与治疗有关的症状与更严重的疲劳有关。实践的意义:由于严重的疲劳与其他癌症症状及其治疗显着相关,因此对这些与癌症相关的症状的筛查和治疗应更加严格,因为它们可能彼此产生负面影响。

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