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Complications of Radiation Therapy for Head and Neck Cancers: The Patient's Perspective.

机译:头颈癌放疗的并发症:患者的观点。

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Newer treatments for head and neck cancers, including altered fractionation and the use of concomitant radiotherapy and chemotherapy, may provide better local-regional tumor control rates; however, patients may experience more frequent and more severe acute toxicities that result in considerable suffering. Through this study, we sought a better understanding of patients' experiences when undergoing radiotherapy. Personal interviews were conducted with 33 individuals who had received radiotherapy for head and neck cancers. These individuals described their treatment experiences and identified the most troublesome and debilitating side effects of radiotherapy. Overall, lethargy and weakness, dry mouth, mouth sores and pain, taste changes, and sore throat were the most frequently reported troublesome or debilitating side effects. The single most debilitating side effect was oropharyngeal mucositis that was characterized by patients as sore throat, and mouth sores and pain; both negatively affected the patient's ability to eat and drink, causing many patients to experience significant weight loss. Trends toward more aggressive management of head and neck cancers underscore the need for new and effective therapies for oropharyngeal mucositis occurring in patients receiving radiotherapy.
机译:较新的头颈癌治疗方法,包括改变分级方法以及同时使用放射疗法和化学疗法,可能会提供更好的局部肿瘤控制率;但是,患者可能会出现更频繁,更严重的急性毒性,从而导致相当多的痛苦。通过这项研究,我们寻求更好地了解患者接受放射治疗时的经历。对接受放射治疗头颈癌的33个人进行了个人访谈。这些人描述了他们的治疗经验,并确定了放射治疗最麻烦和最令人衰弱的副作用。总体而言,嗜睡和虚弱,口干,口疮和疼痛,味觉变化和喉咙痛是最常报告的麻烦或使人衰弱的副作用。最使人衰弱的副作用是口咽粘膜炎,其特征是患者的喉咙痛,口疮和疼痛。两者都会对患者的饮食能力产生负面影响,使许多患者体重明显减轻。积极治疗头颈癌的趋势突显了对于接受放射治疗的患者发生的口咽粘膜炎需要新的有效疗法的需求。

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