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首页> 外文期刊>Measurement Science & Technology >Assessment of bone property using quantitative ultrasound images based on whole calcaneus
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Assessment of bone property using quantitative ultrasound images based on whole calcaneus

机译：使用基于全跟骨的定量超声图像评估骨质

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Osteoporosis is a systemic skeletal disease which leads to bone fragility. It was found that the evaluation of osteoporosis using quantitative ultrasound (QUS) parameters based on the whole calcaneus bone is better than a smaller circular ROI selected from a point with minimum density. Although it was claimed that inhomogeneity of the bone might be the main factor in causing such a difference, other factors, such as phase cancellation might also be the reason. In this paper, a modified contour deformable model (MCDM) was used to automatically detect the calcaneus contour from the QUS images. A three-dimensional calcaneus phantom (CIRS Inc., NV) was first used for the validation of MCDM and the demonstration of the phase cancellation effect. Then, nine subjects were recruited for human testing. From the phantom experiment, it was observed that the correlation coefficient between bone mineral density (BMD) and the parameter (BUA) evaluated based on the ROI selected with the whole calcaneus contour (R velence 0.99) is better than other ROIs. The influence of ROI size, including 12, 14, 16 and 18 mm in diameter, and region-selecting methods, such as fixed region (ROI_(fix)), automatic circular region (ROI_(cir)) and calcaneal contour region (ROI_(anat)), were evaluated for subject testing. The precision errors of the measured ultrasonic parameters for ROI_(anat) (1.02 for BUA, 0.07 for SOS, 0.46 for STI) were smaller than ROI_(fix) (3.75-4.23 for BUA, 0.42-0.54 for SOS, 1.79-2.71 for STI) and ROI_(cir) (1.78-2.85 for BUA, 0.19-0.36 for SOS, 1.60-1.91 for STI). In conclusion, calculating QUS parameters using the whole calcaneal region provides a more precise and optimal measurement than a partial circular region (ROI_(fix) or ROI_(cir)). It has clinical implication that it could increase the diagnostic sensitivity of QUS.
机译：骨质疏松症是导致骨骼脆弱的全身性骨骼疾病。发现使用基于整个跟骨的定量超声（QUS）参数评估骨质疏松症要好于从最小密度点选择的较小圆形ROI。尽管据称骨骼不均匀可能是造成这种差异的主要因素，但其他因素（例如相位抵消）也可能是原因。在本文中，使用改进的轮廓变形模型（MCDM）从QUS图像中自动检测跟骨轮廓。首先使用三维跟骨体模（CIRS Inc.，NV）进行MCDM的验证和相抵消效果的演示。然后，招募了九名受试者进行人体测试。从体模实验中，可以观察到骨矿物质密度（BMD）与基于跟骨整个轮廓选择的ROI（R速度0.99）评估的参数（BUA）之间的相关系数要好于其他ROI。 ROI大小（包括直径为12、14、16和18 mm）以及区域选择方法的影响，例如固定区域（ROI_（fix）），自动圆形区域（ROI_（cir））和跟骨轮廓区域（ROI_ （anat）），进行主题测试评估。 ROI_（anat）的测量超声参数的精度误差（BUA为1.02，SOS为0.07，STI为0.46）小于ROI_（fix）（BUA为3.75-4.23，SOS为0.42-0.54,1.79-2.71 STI）和ROI_（cir）（BUA为1.78-2.85，SOS为0.19-0.36，STI为1.60-1.91）。总之，与部分圆形区域（ROI_（fix）或ROI_（cir））相比，使用整个跟骨区域计算QUS参数可提供更精确和最佳的测量。具有临床意义，它可以提高QUS的诊断敏感性。

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