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Rapid and reversible nuclear accumulation of cytoplasmic tRNA in response to nutrient availability

机译：快速和可逆的细胞质tRNA的核积累响应养分的可获得性

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摘要

Cytoplasmic tRNAs have recently been found to accumulate in the nucleus during amino acid starvation in yeast. The mechanism and regulation by which tRNAs return to the nucleus are unclear. Here, we show accumulation of cytoplasmic tRNA in the nucleus also occurs during glucose starvation. Nuclear accumulation of tRNA in response to acute glucose or amino acid starvation is rapid, reversible, requires no new transcription, and is independent of the aminoacylation status of tRNA. Gradual depletion of nutrients also results in the accrual of tRNA in the nucleus. Distinct signal transduction pathways seem to be involved in the accumulation of cytoplasmic tRNA in the nucleus in response to amino acid versus glucose starvation. These findings suggest tRNA nucleocytoplasmic distribution may play a role in gene expression in response to nutritional stress.
机译：最近发现细胞质的tRNA在酵母中的氨基酸饥饿期间积聚在细胞核中。 tRNA返回细胞核的机制和调控尚不清楚。在这里，我们显示了在葡萄糖饥饿期间细胞核中tRNA的积累也发生了。响应急性葡萄糖或氨基酸饥饿的tRNA的核积累是快速，可逆的，不需要新的转录，并且与tRNA的氨酰化状态无关。营养物质的逐渐消耗还导致核中tRNA的累积。不同的信号转导途径似乎参与了细胞核中的细胞质tRNA的积累，以响应氨基酸与葡萄糖饥饿的关系。这些发现表明，tRNA核质分布可能在营养胁迫下在基因表达中发挥作用。

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