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首页> 外文期刊>Molecular biology of the cell >The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast
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The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast

机译：保守的Spc7蛋白是纺锤体完整性所必需的，并连接裂变酵母中的动粒复合物

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摘要

Spc7, a member of the conserved Spc105/KNL-1 family of kinetochore proteins, was identified as an interaction partner of the EB1 homologue Mal3. Spc7 associates with the central centromere region of the chromosome but does not affect transcriptional silencing. Here, we show that Spc7 is required for the integrity of the spindle as well as for targeting of MIND but not of Ndc80 complex components to the kinetochore. Spindle defects in spc7 mutants were severe ranging from the inability to form a bipolar spindle in early mitosis to broken spindles in midanaphase B. spc7 mutant phenotypes were partially rescued by extra alpha-tubulin or extra Mal2. Thus, Spc7 interacts genetically with the Mal2-containing Sim4 complex.
机译：Spc7是线粒体蛋白保守的Spc105 / KNL-1家族的成员，被确定为EB1同源Mal3的相互作用伴侣。 Spc7与染色体的中央着丝粒区相关联，但不影响转录沉默。在这里，我们表明，Spc7是主轴完整性以及将MIND（而不是Ndc80复杂组件）定位到动粒上所必需的。 spc7突变体的纺锤体缺陷严重，从无法在早期有丝分裂中形成双极纺锤体到中期中期B的纺锤体断裂。spc7突变体的表型可以通过额外的α-微管蛋白或额外的Mal2部分拯救。因此，Spc7与含Mal2的Sim4复合物发生遗传相互作用。

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