...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular biology reports >Matrix Gla protein (MGP) promoter polymorphic variants and its serum level in stenosis of coronary artery
【24h】

Matrix Gla protein (MGP) promoter polymorphic variants and its serum level in stenosis of coronary artery

机译：基质Gla蛋白（MGP）启动子多态性变异及其在冠状动脉狭窄中的血清水平

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although the role of matrix Gla protein (MGP) is not completely known but, its expression within subendothelial macrophages and vascular smooth muscle cells is suggested to be involved in vascular calcification. In this study, we investigated the associations between the serum MGP levels and the MGP promoter high minor allele frequency (MAF) variants with the development of stenosis in coronary arteries. Moreover, we evaluated the allele changes within predicted transcription factor elements with bioinformatics tools. 182 subjects were recruited from who underwent coronary angiography. The MGP promoter rs1800801, rs1800802 and rs1800799 genotypes and haplotypes were detected by ARMS-RFLP PCR techniques. The serum MGP concentration was measured using ELISA method. Jaspar profiles were used for scoring the polymorphic variations within the transcription factor elements. The genotype and two-allelic haplotype distributions were not significant between the patient and control groups (P > 0.05). The serum MGP levels had not significant differences between the genotypes (P > 0.1) and haplotypes (P > 0.4). Based on the prediction studies, we did not observe significant differences between the polymorphic scores in the predicted elements (P > 0.05). We concluded that the genotype and haplotype distributions of the MGP promoter high-MAF polymorphisms, as confirmed in the prediction studies and the serum MGP level are not significantly associated with the coronary artery disease. Based on the study results, the MGP protein did not play an important role in the development of stenosis of coronary arteries.
机译：尽管基质Gla蛋白（MGP）的作用尚不完全清楚，但是它在内皮下巨噬细胞和血管平滑肌细胞中的表达被认为与血管钙化有关。在这项研究中，我们调查了血清MGP水平和MGP启动子高次要等位基因频率（MAF）变异与冠状动脉狭窄发展之间的关系。此外，我们使用生物信息学工具评估了预测的转录因子内的等位基因变化。从接受冠状动脉造影的182名受试者中招募。通过ARMS-RFLP PCR技术检测了MGP启动子rs1800801，rs1800802和rs1800799的基因型和单倍型。使用ELISA法测量血清MGP浓度。 Jaspar谱用于评分转录因子元件内的多态性变异。患者和对照组之间的基因型和两个等位基因单倍型分布不显着（P> 0.05）。血清MGP水平在基因型（P> 0.1）和单倍型（P> 0.4）之间没有显着差异。根据预测研究，我们没有在预测元素中观察到多态性得分之间的显着差异（P> 0.05）。我们得出的结论是，如预测研究所证实的，MGP启动子高MAF多态性的基因型和单倍型分布与血清MGP水平与冠状动脉疾病没有显着相关性。根据研究结果，MGP蛋白在冠状动脉狭窄的发展中不发挥重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号