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首页> 外文期刊>Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging >6-(F-18)fluoro-L-DOPA positron emission tomography in the imaging of Merkel cell carcinoma: preliminary report of three cases with 2-deoxy-2-(F-18)fluoro-D-glucose positron emission tomography or pentetreotide-(111In) SPECT data.
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6-(F-18)fluoro-L-DOPA positron emission tomography in the imaging of Merkel cell carcinoma: preliminary report of three cases with 2-deoxy-2-(F-18)fluoro-D-glucose positron emission tomography or pentetreotide-(111In) SPECT data.

机译：6-（F-18）氟-L-DOPA正电子发射断层显像在默克尔细胞癌中的成像：3例2-脱氧-2-（F-18）氟-D-葡萄糖正电子发射断层显像或戊四肽的初步报道-（111In）SPECT数据

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PURPOSE: Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm of neuroendocrine origin. Somatostatin receptor scintigraphy (SRS) and positron emission tomography (PET) using 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) have been proposed to stage MCC and to detect early recurrences. As 6-[F-18]fluoro-L-DOPA (FDOPA) is taken up by other neuroendocrine tumors, we speculated that FDOPA-PET could image MCC. PROCEDURE: FDOPA-PET was performed together with FDG-PET (three patients) and SRS (two patients) in different clinical settings: localization of the primary tumor, staging, and suspicion of recurrence. RESULTS: Uptake of FDOPA-(18F) by MCC was observed in the two true-positive cases, with an agreement between the results of FDOPA-PET, FDG-PET, and SRS; however, the contrast was lower on FDOPA-PET than on FDG-PET images. In the last patient suspected of recurrence repeatedly on SRS and with inconclusive FDG-PET, FDOPA-PET was negative, and a 12-month follow-up demonstrated a true-negative result. CONCLUSION: MCC takes up FDOPA-(18F). The potential role of FDOPA-PET in its management warrants clarification.
机译：目的：默克尔细胞癌（MCC）是神经内分泌起源的一种罕见的侵袭性皮肤肿瘤。已提出使用2-脱氧-2- [F-18]氟-D-葡萄糖（FDG）的生长抑素受体闪烁显像（SRS）和正电子发射断层显像（PET）来进行MCC分期并检测早期复发。由于6- [F-18]氟-L-DOPA（FDOPA）被其他神经内分泌肿瘤吸收，因此我们推测FDOPA-PET可以对MCC成像。程序：FDOPA-PET与FDG-PET（3例患者）和SRS（2例患者）在不同的临床环境中进行：原发肿瘤的定位，分期和怀疑复发。结果：在两个真实阳性病例中，MCC摄取了FDOPA-（18F），FDOPA-PET，FDG-PET和SRS结果一致。但是，FDOPA-PET的对比度低于FDG-PET图像。在最后一名疑似在SRS上反复复发且不确定的FDG-PET的患者中，FDOPA-PET阴性，并且12个月的随访显示为真实阴性结果。结论：MCC占用FDOPA-（18F）。 FDOPA-PET在其管理中的潜在作用值得澄清。

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