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首页> 外文期刊>Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging >[ 11C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results
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[ 11C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results

机译：[11C]醋酸PET / CT可显示骨骼肌运动参与，功能受损和髋关节置换术后的恢复情况;第一结果

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Purpose: Based on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [ 11C]acetate PET. Procedures: Two male patients were investigated 3 and 12 weeks after hip arthroplasty with muscle [ 11C]acetate PET/CT performed at rest and exercise. Median muscle SUV mean were calculated on three non-consecutive transverse PET slices. Results: The four exercise PET/CT showed, compared with rest, consistent increase in [ 11C] acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12 weeks after surgery, but four muscles showed only minor activity increase at 3 weeks. At 3 months, functional recovery of the latter four muscles was observed. Conclusion: Consistent increase in [ 11C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation.
机译：目的：基于骨骼肌醋酸盐生理学，我们旨在研究用[11C]醋酸盐PET进行髋关节置换术后的肌肉功能。程序：对两名男性患者进行了髋关节置换术后3周和12周，并在休息和运动时进行了肌肉[11C]醋酸盐PET / CT手术。在三个非连续的横向PET切片上计算了肌肉SUV的中位数。结果：与休息相比，四次运动PET / CT显示，与手术相对的活动肌肉中[11C]乙酸盐摄取量持续增加。在关节置换方面，大多数肌肉在手术后第3周和第12周在运动下均表现出对称性活动的增加，但在第3周时，只有4条肌肉在运动后对称性活动的增加。在3个月时，观察到后四块肌肉的功能恢复。结论：与静止相比，运动后健康肌肉的[11C]乙酸酯摄取量持续增加。手术后3周，肌肉功能暂时受损，三个月后恢复。这些初步观察值得进一步研究。

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