Protein quality control of cell stemness

Yan P.; Ren J.; Zhang W.Qu J.Liu G.-H.

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Protein quality control of cell stemness

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© 2020, The Author(s).Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefore, accurate PQC systems are essential to maintain stem cell function. Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells. This review focuses on current knowledge regarding the components of the proteostasis network in stem cells, and the importance of proteostasis in maintaining stem cell identity and regenerative functions. A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases.

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《cell regeneration》 |2020年第1期|共页
作者
Yan P.; Ren J.; Zhang W.Qu J.Liu G.-H.;
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作者单位

State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences;

University of Chinese Academy of Sciences;

China National Center for BioinformationCAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and Development Beijing Institute of Genomics Chinese Academy of SciencesInstitute for Stem cell and Regeneration Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of SciencesBeijing Institute for Brain Disorders Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University;

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正文语种英语
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Autophagy; Chaperones; Protein quality control; Stem cells; Stemness; Ubiquitin-proteasome system; Unfolded protein response;

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Protein quality control of cell stemness

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