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首页> 外文期刊>Molecular interventions >A bacterial sensory system that activates resistance to innate immune defenses: potential targets for antimicrobial therapeutics.
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A bacterial sensory system that activates resistance to innate immune defenses: potential targets for antimicrobial therapeutics.

机译：激活对先天性免疫防御的抵抗力的细菌感觉系统：抗菌治疗的潜在目标。

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摘要

Bacteria posses multiple two component regulatory systems consisting typically of a kinase and a transcription factor that, in concert, monitor the concentrations of particular extracellular factors and regulate specific gene expression accordingly. Salmonella possess PhoP-PhoQ, which are activated under conditions of suboptimal [Mg(2+)] and result in gene expression leading to greater stability of the outer membrane. New research identifies PhoQ as a receptor for sublethal concentrations of antimicrobial peptides (AMPs), adapting bacteria for survival. The development of AMPs that do not activate Phop-PhoQ, however, should proceed with great caution: AMPs are part of the host innate immune response and bacterial resistance to newly developed AMPs could possibly lead to intractable infection in immunocompetent hosts.
机译：细菌具有两个组成部分的调节系统，通常由激酶和转录因子组成，它们共同监测特定细胞外因子的浓度并相应地调节特定基因的表达。沙门氏菌具有PhoP-PhoQ，可在次优[Mg（2+）]条件下将其激活，并导致基因表达导致外膜更大的稳定性。新的研究确定PhoQ是亚致死浓度的抗菌肽（AMPs）的受体，可以使细菌存活。然而，不激活Phop-PhoQ的AMP的开发应格外谨慎：AMP是宿主固有免疫反应的一部分，细菌对新开发的AMP的耐药性可能导致免疫能力强的宿主顽固感染。

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