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首页> 外文期刊>Cancer prevention research. >Opportunities for Preventing Esophageal Adenocarcinoma
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Opportunities for Preventing Esophageal Adenocarcinoma

机译：预防食管腺癌的机会

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Esophageal adenocarcinoma (EAC) is rapidly increasing in incidence in many Western societies, requires demanding treatment, and is associated with a poor prognosis, therefore preventive measures are highly warranted. To assess the opportunities for prevention, we reviewed the available literature and identified seven main potentially preventive targets. Preventive effects were found on the basis of medium-level observational evidence following treatment of gastroesophageal reflux disease (using both medication and surgery) and tobacco smoking cessation, which should be clinically recommended among exposed patients. Nonsteroidal anti-inflammatory drugs appear to prevent EAC, and the limited existing data also indicate a protective effect of medication with statins or hormone replacement therapy in women, but current evidence is insufficient to guide clinical decision-making regarding these drugs. The evidence is presently insufficient to assess the potentially preventive role of weight loss. Whether avoidance of eradication of Helicobacter pylori prevents EAC is not studied, but there is no evidence that such eradication increases symptoms of gastroesophageal reflux or prevalence of erosive esophagitis. The introduction of preventive actions should be tailored toward high-risk individuals, that is, older men with obesity and gastroesophageal reflux disease and individuals with Barrett esophagus rather than the population at large. (C) 2016 AACR.
机译：在许多西方社会中，食管腺癌（EAC）的发病率迅速增加，需要严格的治疗，并且预后不良，因此必须采取预防措施。为了评估预防的机会，我们回顾了现有文献并确定了七个主要的潜在预防目标。在治疗胃食管反流病（同时使用药物和外科手术）和戒烟后，根据中等水平的观察证据发现了预防作用，应在暴露的患者中临床上建议这样做。非甾体类抗炎药似乎可以预防EAC，现有的有限数据也表明，他汀类药物或激素替代疗法对女性具有保护作用，但目前的证据不足以指导有关这些药物的临床决策。目前证据不足以评估减肥的潜在预防作用。尚未研究是否避免根除幽门螺杆菌会阻止EAC，但没有证据表明这种根除会增加胃食管反流症状或糜烂性食管炎的流行。预防措施的引入应针对高危人群，即肥胖和胃食管反流疾病的老年男性和巴雷特食管患者而不是整个人群。 （C）2016 AACR。

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