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首页> 外文期刊>Cancer prevention research. >The Dose-Response Effects of Aerobic Exercise on Body Composition and Breast Tissue among Women at High Risk for Breast Cancer: A Randomized Trial
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The Dose-Response Effects of Aerobic Exercise on Body Composition and Breast Tissue among Women at High Risk for Breast Cancer: A Randomized Trial

机译：有氧运动对乳腺癌高危女性的身体成分和乳房组织的剂量反应效应：一项随机试验。

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Observational data indicate that behaviors that shift energetic homeostasis, such as exercise, may decrease the risk of developing breast cancer by reducing the amount of energy-dense, metabolically active adipose tissue. Between December 2008 and April 2013, we conducted a single-blind, 5-month, clinical trial that randomized premenopausal women at high risk of developing breast cancer to one of three groups: 150 min/wk of aerobic exercise (low dose), 300 min/wk of aerobic exercise (high dose), or control. Body composition was assessed using dual-energy x-ray absorptiometry. Background parenchymal enhancement (BPE) was quantified using computerized algorithms on breast dynamic contrast-enhanced MRI. Over 5 months, compared with the control group: the low-dose and high-dose groups lost -1.5 +/- 0.5 and -1.3 +/- 0.5 kg of body mass (linear P-trend = 0.032); -1.5 +/- 0.4 and -1.4 +/- 0.3 kg of fat mass (linear P-trend = 0.003); -1.3 +/- 0.3 and -1.4 +/- 0.3% of body fat (linear P-trend < 0.001); -15.9 +/- 5.4 and -26.6 +/- 5.0 cm(2) of subcutaneous adipose tissue (linear Ptrend < 0.001); and -6.6 +/- 1.9 and -5.0 +/- 1.9 cm2 visceral adipose tissue (nonlinear P-trend - 0.037). For each -1 cm(2) reduction in visceral adipose tissue, BPE decreased by -3.43 +/- 1.34 cm(2) (P = 0.010) and explained 9.7% of the variability in BPE. Changes in other aforementioned body composition outcomes did not significantly correlate with changes in BPE. These mechanistic data support observational evidence that shifting energetic homeostasis through exercise may alter the risk of developing breast cancer. Additional adequately powered studies are needed to confirm and expand upon our findings that changes in body composition are associated with changes in BPE. Cancer Prev Res; 9(7); 581-8. (C) 2016 AACR.
机译：观测数据表明，改变能量平衡的行为，例如运动，可以通过减少能量密集，代谢活跃的脂肪组织的数量来降低患乳腺癌的风险。在2008年12月至2013年4月之间，我们进行了一项为期5个月的单盲临床试验，该试验将绝大部分患有乳腺癌的高风险绝经前妇女随机分为三组：每分钟150分钟有氧运动（低剂量），300分钟有氧运动（高剂量）或对照的分钟/周。使用双能X射线吸收法评估身体组成。使用计算机算法对乳腺动态对比增强MRI定量背景实质增强（BPE）。与对照组相比，超过5个月的时间：低剂量和高剂量组的体重减轻了-1.5 +/- 0.5和-1.3 +/- 0.5 kg（线性P趋势= 0.032）; -1.5 +/- 0.4和-1.4 +/- 0.3千克脂肪质量（线性P趋势= 0.003）;体脂肪的-1.3 +/- 0.3和-1.4 +/- 0.3％（线性P趋势<0.001）;皮下脂肪组织的-15.9 +/- 5.4和-26.6 +/- 5.0 cm（2）（线性Ptrend <0.001）;和-6.6 +/- 1.9和-5.0 +/- 1.9 cm2内脏脂肪组织（非线性P趋势-0.037）。对于内脏脂肪组织每减少-1 cm（2），BPE就会降低-3.43 +/- 1.34 cm（2）（P = 0.010），并解释BPE变异的9.7％。其他上述身体成分结局的变化与BPE的变化没有显着相关。这些机制数据支持观察证据，即通过运动转移能量稳态可能会改变患乳腺癌的风险。需要进行其他有力的研究来确认和扩展我们的发现，即身体成分的变化与BPE的变化有关。癌症预防9（7）; 581-8。 （C）2016 AACR。

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