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首页> 外文期刊>Molecular medicine reports >Effects of combining low-dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome
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Effects of combining low-dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome

机译：小剂量阿司匹林与中成药合用对卵泡血流量和妊娠结局的影响

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摘要

The aim of the present study was to investigate the clinical value of low-dose aspirin in combination with Tiao Jing Cu Yun pills in patients with polycystic ovary syndrome (PCOS) by measuring follicular peripheral blood flow parameters and the clinical efficacy. The study involved 78 infertile females with PCOS who were randomly divided into experimental (n=38) and control (n=40) groups. The subjects in the experimental group were treated with letrozole in combination with aspirin and Tiao Jing Cu Yun pills, and the control group was treated with letrozole alone. Transvaginal color Doppler ultrasonography was used to measure the endometrial thickness, pulsatility index (PI), resistance index (RI), peak systolic velocity and end diastolic velocity (EDV) of the follicular peripheral artery on the day of human chorionic gonadotropin administration. The patients who failed to become pregnant in the control group were reintegrated into the experimental group in the subsequent cycle and the clinical effect was observed. In the experimental group, subject perifollicular blood flow was more plentiful, and the PI and RI of the perifollicular blood flow were significantly reduced, while the EDV of the perifollicular blood, flow and the rate of clinical pregnancy were markedly elevated compared with the subjects in the control group. Low-dose aspirin combined with Tiao Jing Cu Yun pills effectively improved perifollicular artery blood flow, and enhanced the oocyte quality and rate of clinical pregnancy.
机译：本研究的目的是通过测量卵泡外周血流量参数和临床疗效，研究低剂量阿司匹林联合调经Cu Yun丸在多囊卵巢综合征（PCOS）患者中的临床价值。该研究纳入了78名PCOS不育女性，这些女性被随机分为实验组（n = 38）和对照组（n = 40）。实验组的受试者接受来曲唑联合阿司匹林和调经铜运丸的治疗，对照组则单独接受来曲唑的治疗。在使用绒毛膜促性腺激素的当天，使用阴道彩色多普勒超声测量卵泡周围动脉的子宫内膜厚度，搏动指数（PI），阻力指数（RI），收缩期峰值速度和舒张末期速度（EDV）。对照组未能怀孕的患者在随后的周期中重新纳入实验组，并观察其临床效果。在实验组中，受试者的毛囊周血流量更丰富，并且毛囊周血的PI和RI显着降低，而与之相比，毛囊周血的EDV，血流量和临床妊娠率显着升高。对照组。小剂量阿司匹林联合调经祛瘀丸有效改善了毛囊周动脉血流量，提高了卵母细胞的质量和临床妊娠率。

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