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首页> 外文期刊>Molecular medicine reports >FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis
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FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis

机译：FSH加重了实验性根尖周炎的卵巢切除大鼠的骨质流失

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摘要

Periapical bone loss is one of the prominent pathological and clinical features of periapical periodontitis. Previous studies have demonstrated that follicle-stimulating hormone (FSH) could directly affect skeletal remodelling by stimulating the formation and the function of osteoclasts in vitro and in vivo. However, the effect of FSH on periapical bone loss remained to be fully elucidated. In the current study, a rat model was established in order to verify the effect of FSH in experimental periapical lesions. It was identified that FSH aggravated the bone loss of periapical lesions. In addition, RANKL-, TRAP-, TNF-- and IL-1-positive cells were increased significantly in FSH-treated groups, which indicated that the function of FSH in bone loss may be mediated through the increasing activity of osteoclasts and the increased secretion of inflammatory cytokines. The results of the current study suggested that FSH, independent of oestrogen, may aggravate periapical bone loss by FSH receptors, which may serve an important role in the immune and inflammatory response of the host to root canal and periradicular infection during menopause.
机译：根尖周骨丢失是根尖周周炎的主要病理和临床特征之一。先前的研究表明，促卵泡激素（FSH）可以通过在体外和体内刺激破骨细胞的形成和功能直接影响骨骼重塑。然而，FSH对根尖周骨质流失的影响仍有待充分阐明。在当前研究中，建立了大鼠模型以验证FSH在实验性根尖周病变中的作用。已确认FSH加重了根尖周病变的骨丢失。此外，FSH治疗组的RANKL，TRAP，TNF和IL-1阳性细胞显着增加，这表明FSH在骨丢失中的功能可能是通过破骨细胞活性的增加和增加而介导的。炎性细胞因子的分泌。目前的研究结果表明，FSH独立于雌激素，可能加剧FSH受体引起的根尖周骨质流失，这可能在更年期宿主对根管和根尖周感染的免疫和炎症反应中起重要作用。

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