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首页> 外文期刊>Molecular medicine today >Knowing left from right: the molecular basis of laterality defects.
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Knowing left from right: the molecular basis of laterality defects.

机译:从右到左:横向缺陷的分子基础。

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摘要

The apparent symmetry of the vertebrate body conceals profound asymmetries in the development and placement of internal organs. Asymmetric organ development is controlled in part by genes expressed asymmetrically in the early embryo, and alterations in the activities of these genes can result in severe defects during organogenesis. Recently, data from different vertebrates have allowed researchers to put forward a model of genetic interactions that explains how asymmetric patterns of gene expression in the early embryo are translated into spatial patterns of asymmetric organ development. This model helps us to understand the molecular basis of a number of congenital malformations in humans.
机译:脊椎动物身体的明显对称性掩盖了内部器官发育和放置中的严重不对称性。不对称器官的发育部分受早期胚胎中不对称表达的基因控制,这些基因活性的改变可导致器官发生过程中的严重缺陷。最近,来自不同脊椎动物的数据使研究人员提出了一种遗传相互作用模型,该模型解释了早期胚胎中基因表达的不对称模式如何转化为不对称器官发育的空间模式。该模型有助于我们了解人类中许多先天性畸形的分子基础。

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