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首页> 外文期刊>Molecular medicine reports >Mangiferin attenuates contusive spinal cord injury in rats through the regulation of oxidative stress, inflammation and the Bcl-2 and Bax pathway
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Mangiferin attenuates contusive spinal cord injury in rats through the regulation of oxidative stress, inflammation and the Bcl-2 and Bax pathway

机译：芒果苷通过调节氧化应激，炎症以及Bcl-2和Bax途径减轻大鼠挫伤性脊髓损伤

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Mangiferin has antioxidant, antiviral, apoptosis regulating, anti-inflammatory, antitumor and antidiabetic effects, which can also inhibit osteoclast formation and bone resorption. However, whether mangiferin ameliorates the neurological pain of spinal cord injury (SCI) in ratS remains to be elucidated. The present study investigated the therapeutic effects of mangiferin on neurological function, the water content of spinal cord, oxidative stress, the expression of inflammatory cytokines and the protein expression of Bcl-2/Bax in a SCI rat model. In the present study, the Basso, Beattie and Bresnahan scores, and the water content of the spinal cord were used to analyze the therapeutic effects of mangiferin on neurological pain in the SCI rat. The concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and the serum levels of glutathione peroxidase (GSH-PX), nuclear factor-kappa B p65 unit, tumor necrosis factor-a, interleukin (IL)-1 beta, IL-6 and caspase-3/9 were detected using commercial kits. The expression levels of Bcl-2 and Bax were measured using western blot analysis. The results demonstrated that administrating mangiferin began to ameliorate neurological function and the water content of the spinal cord in the SCI rat. The mangiferin-treated group were found to have lower oxidative stress activity and lower expression levels of inflammatory cytokines, compared with the SCI rat. In addition, mangiferin significantly reduced the protein expression of Bax and promoted the protein expression of Bcl-2 in the SCI rat model. Finally, mangiferin markedly suppressed the expression of caspase-3/9, indicating that the protective action of mangiferin may be associated with anti-apoptosis activation. In conclusion, mangiferin attenuated contusive SCI in the rats through regulating oxidative stress, inflammation and the Bcl-2 and Bax pathway.
机译：芒果苷具有抗氧化，抗病毒，调节细胞凋亡，抗炎，抗肿瘤和抗糖尿病作用，还可以抑制破骨细胞形成和骨吸收。然而，芒果苷是否能减轻大鼠脊髓损伤（SCI）的神经系统疼痛尚待阐明。本研究调查了芒果苷对SCI大鼠模型的神经功能，脊髓含水量，氧化应激，炎性细胞因子的表达以及Bcl-2 / Bax蛋白表达的治疗作用。在本研究中，使用Basso，Beattie和Bresnahan评分以及脊髓中的水分来分析芒果苷对SCI大鼠神经痛的治疗作用。丙二醛（MDA），超氧化物歧化酶（SOD），过氧化氢酶（CAT）的浓度以及血清谷胱甘肽过氧化物酶（GSH-PX），核因子-κBp65单位，肿瘤坏死因子-a，白介素（IL）的浓度使用商业试剂盒检测到-1 beta，IL-6和caspase-3 / 9。使用蛋白质印迹分析测量Bcl-2和Bax的表达水平。结果表明，服用芒果苷开始改善SCI大鼠的神经功能和脊髓含水量。与SCI大鼠相比，芒果苷治疗组被发现具有较低的氧化应激活性和较低的炎性细胞因子表达水平。另外，芒果苷显着降低了SCI大鼠模型中Bax的蛋白表达并促进了Bcl-2的蛋白表达。最后，芒果苷显着抑制了caspase-3 / 9的表达，表明芒果苷的保护作用可能与抗凋亡激活有关。总之，芒果苷通过调节氧化应激，炎症以及Bcl-2和Bax途径减轻了大鼠的挫伤性脊髓损伤。

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