...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular ecology >Complexity of the genetic basis of ageing in nature revealed by a clinal study of lifespan and methuselah, a gene for ageing, in Drosophila from eastern Australia
【24h】

Complexity of the genetic basis of ageing in nature revealed by a clinal study of lifespan and methuselah, a gene for ageing, in Drosophila from eastern Australia

机译：对来自澳大利亚东部果蝇的寿命和衰老基因methuselah的临床研究揭示了自然衰老的遗传基础的复杂性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Clinal studies are a powerful tool for understanding the genetic basis of climatic adaptation. However, while clines in quantitative traits and genetic polymorphisms have been observed within and across continents, few studies have attempted to demonstrate direct links between them. The gene methuselah in Drosophila has been shown to have a major effect on stress response and longevity phenotypes based largely on laboratory studies of induced mutations in the mth gene. Clinal patterns in the most common mth haplotype and for lifespan (both increasing with latitude) have been observed in North American populations of D. melanogaster, implicating climatic selection. While these clinal patterns have led some to suggest that mth influences ageing in natural populations, limited evidence on the association between the two has so far been collected. Here, we describe a significant cline in the mth haplotype in eastern Australian D. melanogaster populations that parallel the cline in North America. We also describe a cline in mth gene expression. These findings further support the idea that mth is itself under selection. In contrast, we show that lifespan has a strong nonlinear clinal pattern, increasing southwards from the tropics, but then decreasing again from mid-latitudes. Furthermore, in association studies, we find no evidence for a direct link between mth haplotype and lifespan. Thus, while our data support a role for mth variation being under natural selection, we found no link to naturally occurring variation in lifespan and ageing in Australian populations of D. melanogaster. Our results indicate that the mth locus likely has genetic background and environment-specific effects.
机译：临床研究是了解气候适应的遗传基础的有力工具。但是，虽然在各大洲内部和整个大陆都观​​察到了数量特征和遗传多态性的种系，但很少有研究试图证明它们之间的直接联系。果蝇中的methuselah基因已显示出对应激反应和长寿表型的重要影响，这主要是基于对mth基因诱导突变的实验室研究得出的。在北美的D. melanogaster种群中观察到了最常见的第m个单倍型和寿命（随纬度增加）的斜纹样，暗示了气候选择。虽然这些渐进模式导致一些人暗示了甲基苯丙氨酸会影响自然种群的衰老，但迄今为止，关于两者之间联系的证据有限。在这里，我们描述了在澳大利亚东部的D. melanogaster种群中，与北美的cline相似的第m个单倍型的重要cline。我们还描述了mth基因表达中的一个系。这些发现进一步支持了mth本身正在选择的想法。相反，我们表明，寿命具有很强的非线性倾斜模式，从热带向南增加，但从中纬度再次减少。此外，在关联研究中，我们没有发现第m个单倍型与寿命之间存在直接联系的证据。因此，尽管我们的数据支持在自然选择下第m变异的作用，但我们发现与澳大利亚D. melanogaster种群的寿命和衰老的自然变异没有联系。我们的结果表明，第m个基因座可能具有遗传背景和环境特异性作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号