Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression in human prostate cancer cells.

Miyagi T; Hori O; Egawa M; Kato H; Kitagawa Y; Konaka H; Ozawa K; Koshida K; Uchibayashi T; Ogawa S; Namiki M

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Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression in human prostate cancer cells.

机译：减少人类前列腺癌细胞中150 kDa氧调节的蛋白表达的抗肿瘤作用。

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Heat shock proteins (HSPs)/stress proteins are molecular chaperones that are induced by various environmental and physiological stimuli. Evidence of the relations between the expression of HSPs and the regulation of cell growth or transformation has accumulated. The 150-kDa oxygen-regulated protein (ORP150), a new member of HSP family, functions as a molecular chaperone in the endoplasmic reticulum. We have examined whether transduced antisense ORP150 cDNA reduces tumorigenicity and angiogenicity. Relations between these stress proteins and cancer and possibilities for anticancer gene therapy are described.

机译：热休克蛋白（HSP）/应激蛋白是由各种环境和生理刺激诱导的分子伴侣。已经积累了HSP表达与细胞生长或转化调控之间关系的证据。 150 kDa的氧气调节蛋白（ORP150）是HSP家族的新成员，在内质网中起分子伴侣的作用。我们已经检查了转导的反义ORP150 cDNA是否降低了致瘤性和血管生成性。描述了这些应激蛋白与癌症之间的关系以及抗癌基因治疗的可能性。

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《Molecular urology》 |2001年第2期|共2页
作者
Miyagi T; Hori O; Egawa M; Kato H; Kitagawa Y; Konaka H; Ozawa K; Koshida K; Uchibayashi T; Ogawa S; Namiki M;
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正文语种 eng
中图分类妇产科学;
关键词
Prostatic Neoplasms; Proteins; 前列腺肿瘤; 蛋白质类;

机译：Prostatic Neoplasms;Proteins;前列腺肿瘤;蛋白质类;

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1. Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression on human prostate cancer cells. [J] . Miyagi T, Hori O, Koshida K, International journal of urology: official journal of the Japanese Urological Association . 2002,第10期

机译：减少150 kDa氧调节的蛋白表达对人前列腺癌细胞的抗肿瘤作用。
2. Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. [J] . Namba T, Hoshino T, Tanaka K, Molecular pharmacology. . 2007,第3期

机译：塞来昔布在人胃癌细胞中上调150 kDa的氧调节蛋白。
3. Antitumor effect of an HER2-specific antibody-toxin fusion protein on human prostate cancer cells. [J] . Wang L, Liu B, Schmidt M, The Prostate . 2001,第1期

机译：HER2特异性抗体-毒素融合蛋白对人前列腺癌细胞的抗肿瘤作用。
4. SUBCELLULAR LOCALIZATION OF ZNFD: A NOVEL HUMAN ZINC FINGER PROTEIN AND THE EXPRESSION AND ITS SIGNIFICANCE OF ZNFD IN PROSTATE CANCER TISSUES [C] . Cheng Hongxia, Wang Weiping, Sun Libing, Progress on post-genome technologies and modern natural products . 2011

机译：ZNFD的亚细胞定位：一种新型人类锌指蛋白及其在前列腺癌组织中的表达及其意义
5. Regulation of the tumor suppressor pRB by protein kinase Cepsilon in human prostate cancer cells. [D] . Foreman, Tonia Lee. 2003

机译：蛋白激酶Cepsilon在人前列腺癌细胞中对抑癌基因pRB的调节。
6. Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. [O] . Irina Ianculescu, Dai-Ying Wu, Kimberly D. Siegmund, 2012

机译：cAMP反应元件结合蛋白结合蛋白和p300蛋白作为雄激素调节晚期前列腺癌细胞基因表达的核心调节剂的选择性作用。
7. Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells. [O] . Kazumasa Sekihara, Nanae Harashima, Miki Tongu, 2013

机译：pifithrin-μ是热休克蛋白70的抑制剂，可以增加高温对抗人前列腺癌细胞的抗肿瘤作用。

Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression in human prostate cancer cells.

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