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Strategies for Optimizing Water-Exchange Rates of Lanthanide-Based Contrast Agents for Magnetic Resonance Imaging

机译：用于磁共振成像的基于镧系元素的造影剂的水交换率优化策略

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摘要

This review describes recent advances in strategies for tuning the water-exchange rates of contrast agents for magnetic resonance imaging (MRI). Water-exchange rates play a critical role in determining the efficiency of contrast agents; consequently, optimization of water-exchange rates, among other parameters, is necessary to achieve high efficiencies. This need has resulted in extensive research efforts to modulate water-exchange rates by chemically altering the coordination environments of the metal complexes that function as contrast agents. The focus of this review is coordination-chemistry-based strategies used to tune the water-exchange rates of lanthanide(III)-based contrast agents for MRI. Emphasis will be given to results published in the 21st century, as well as implications of these strategies on the design of contrast agents.
机译：这篇综述描述了调整磁共振成像（MRI）造影剂的水交换率策略的最新进展。水分交换率在确定造影剂的效率中起着至关重要的作用。因此，除其他参数外，水交换率的优化对于实现高效率是必要的。这种需求导致了广泛的研究努力，以通过化学改变充当造影剂的金属络合物的配位环境来调节水交换速率。这篇综述的重点是基于协调化学的策略，用于调整基于镧系元素（Ⅲ）的造影剂的水交换率。将重点介绍21世纪发表的结果，以及这些策略对造影剂设计的影响。

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