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首页> 外文期刊>Multiple sclerosis: clinical and laboratory research >Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients.
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Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients.

机译：比较多焦点视觉诱发电位，标准自动视野检查和光学相干断层扫描在评估多发性硬化症患者的视觉通路中的作用。

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BACKGROUND: Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision. OBJECTIVE: To compare the sensitivity of mfVEP, Humphrey visual field (HVF) and optical coherence tomography (OCT) in detecting visual abnormality in multiple sclerosis (MS) patients. METHODS: mfVEP, HVF, and OCT (retinal nerve fiber layer [RNFL]) were performed in 47 MS-ON eyes (last optic neuritis [ON] attack >or=6 months prior) and 65 MS-no-ON eyes without ON history. Criteria to define an eye as abnormal were: (1) mfVEP amplitude/latency - either amplitude or latency probability plots meeting cluster criteria with 95% specificity; (2) mfVEP amplitude or latency alone (specificity: 97% and 98%, respectively); and (3) HVF and OCT, mean deviation and RNFL thickness meeting p < 0.05, respectively. RESULTS: MfVEP (amplitude/latency) identified more abnormality in MS-ON eyes (89%) than HVF (72%), OCT (62%), mfVEP amplitude (66%) or latency (67%) alone. Eighteen percent of MS-no-ON eyes were abnormal for both mfVEP (amplitude/latency) and HVF compared with 8% with OCT. Agreement between tests ranged from 60% to 79%. mfVEP (amplitude/latency) categorized an additional 15% of MS-ON eyes as abnormal compared with HVF and OCT combined. CONCLUSIONS: mfVEP, which detects both demyelination (increased latency) and neural degeneration (reduced amplitude), revealed more abnormality than HVF or OCT in MS patients.
机译：背景：多焦点视觉诱发电位（mfVEP）测量视野中的局部反应幅度和潜伏期。目的：比较mfVEP，汉弗莱视野（HVF）和光学相干断层扫描（OCT）检测多发性硬化症（MS）患者视觉异常的敏感性。方法：在47只MS-ON眼（最后视神经炎[ON]发作>或= 6个月前）和65只MS-on-ON眼未进行ON的情况下，进行了mfVEP，HVF和OCT（视网膜神经纤维层[RNFL]）检查历史。将眼睛定义为异常的标准是：（1）mfVEP振幅/潜伏期-满足簇标准且具有95％特异性的振幅或潜伏期概率图; （2）仅mfVEP振幅或潜伏期（特异性分别为97％和98％）; （3）HVF和OCT，均值偏差和RNFL厚度分别满足p <0.05。结果：MfVEP（振幅/潜伏期）比单独的HVF（72％），OCT（62％），mfVEP振幅（66％）或潜伏期（67％）发现MS-ON眼（89％）异常更多。 mfVEP（振幅/潜伏期）和HVF的MS-on-ON眼睛中有18％异常，而OCT则为8％。测试之间的一致性从60％到79％不等。与HVF和OCT相结合，mfVEP（振幅/潜伏期）将另外15％的MS-ON眼归为异常。结论：mfVEP可同时检测脱髓鞘（潜伏期增加）和神经变性（振幅降低），与MS患者的HVF或OCT相比，显示出更多的异常。

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