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首页> 外文期刊>Mycopathologia >Cutaneous Phaeohyphomycosis Caused by Exophiala attenuata in a Domestic Cat
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Cutaneous Phaeohyphomycosis Caused by Exophiala attenuata in a Domestic Cat

机译：犬猫Exophiala造成的皮肤性皮肤萎缩症

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摘要

A 7-year-old female-spayed, domestic short-haired cat was presented to her veterinarian with a mass on the hind paw. Histopathologic examination of a tissue biopsy revealed nodular pyogranulomatous panniculitis with intralesional pigmented fungal hyphae. A dematiaceous fungal isolate was isolated with a micromorphological phenotype consistent with the anamorphic genus Exophiala: budding cells, torulose mycelium and annellidic conidiogenesis from simple conidiophores consisting of terminal and lateral cells that tapered to a short beak at the apex. Sequence homology of the internal transcribed spacer region of the rDNA gene confirmed the identification of the isolate as Exophiala attenuata. Reported here is the first confirmed case of feline phaeohyphomycosis caused by E. attenuata in North America. Similar to historical cases of feline phaeohyphomycosis caused by Exophiala spp., there was no history or postmortem evidence to suggest the patient was in an immunocompromised state (e.g., suffering from FeLV or FIV). Although aggressive surgical excision of local lesions is recommended prior to drug treatment when dealing with subcutaneous phaeohyphomycosis, surgery followed by itraconazole treatment did not resolve the E. attenuata infection in this cat.
机译：一只7岁的雌性付费家养短毛猫被送给兽医，后爪上有肿块。组织活检的组织病理学检查显示结节性肾盂肉芽肿性脂膜炎伴病灶内色素沉着真菌菌丝。分离出具有与变形属外来属一致的微形态表型的皮肤病真菌分离株：从简单的分生孢子中萌芽的细胞，to状菌丝体和年生的分生孢子，该分生孢子由在顶端逐渐变细为短喙的末端和侧生细胞组成。 rDNA基因的内部转录间隔区的序列同源性证实了该分离株的鉴定为Exophiala activatea。此处报道的是北美地区首例确诊的由弱毒性大肠杆菌引起的猫甲表皮真菌病。与由Exophiala spp。引起的猫性继发性真菌病的历史病例相似，没有历史或验尸证据表明该患者处于免疫功能低下状态（例如，患有FeLV或FIV）。尽管在处理皮下继发性真菌病时，建议在药物治疗之前积极手术切除局部病变，但是在伊塔康唑治疗后手术不能解决这只猫的减毒大肠杆菌。

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