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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >In vivo short-term assays for tumor initiation and promotion in the glandular stomach of Fischer rats
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In vivo short-term assays for tumor initiation and promotion in the glandular stomach of Fischer rats

机译：费希尔大鼠腺胃中肿瘤起始和促进的体内短期测定

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Here we summarize the data on 55 compounds tested in in vivo short-term assays for tumor-Initiating and tumor-promoting activity in the glandular stomach of male Fischer (F344) rats. Most of the data has been previously published. Junior-initialing, activity was assayed by measuring the induction of unscheduled DNA synthesis (UDS) and DNA single strand scission: tumor-promoting activity was assayed by measuring the induction of ornithinc dccurboxylasc (ODC) activity, increased replicutivc DNA synthesis (RDS), and of c-fos and c-myc oneogene expression. The compounds were orally administered. Twenty-nine compounds were tested for UDS. Eight were positive, including 5 glandular stomach carcinogens; 16 were negative, including 5 liver carcinogens; and5 were equivocal. Twenty compounds were tested for DNA single strand scission, Twelve were positive, including 6 glandular stomach carcinogens; 7 negative, including 2 liver carcinogen's; and 1 was equivocal. Thirty-two compounds were tested for RDS. Twenty-six were positive, including 8 glandular stomach carcinogens and 6 glandular stomach tumor-promoters; 4 were negative, including 3 liver carcinogens and a stomach irritant; and 2 were equivocal. Forty-five compounds were tested for ODC. Thirty-sevenwere positive, including 8 glandular stomach carcinogens and a glandular stomach tumor promoters; 7 wen? negative, including 3 liver carcinogens; and one WHS equivocal. All glandular stomach carcinogens and tumor-promoters examined were positive in bothRDS and ODC. Two compounds .wen- icsttd for c-fos and c-myc expression; one was a glandular stomach carcinogen and one was a glandular stomach'tumor promoter, and both were positive. In addition, 2 compounds inhibited the Increase in RDS induced by the tumor promoter NaCl, suggesting awkumor-promoter activity. Thus these assays are useful for assessing poiential tumor-initiating and tumor-promoting activity in the rat glandular stomach.
机译：在这里，我们总结了在雄性Fischer（F344）大鼠的腺胃中通过体内短期试验测试的55种化合物的肿瘤启动和促肿瘤活性的数据。大多数数据以前已经发布过。通过测量计划外DNA合成（UDS）和DNA单链断裂的诱导来测定初次活性：通过测量鸟氨酸dccurboxylasc（ODC）活性的诱导来测定促肿瘤活性，复制性DNA合成（RDS）的增加，以及c-fos和c-myc oneogene表达。化合物经口服给药。测试了29种化合物的UDS。 8例为阳性，其中5例为胃部胃癌。阴性16例，其中5种是肝致癌物。和5是模棱两可的。测试了20种化合物的DNA单链断裂，其中12例呈阳性，其中包括6种胃腺癌致癌物。阴性7例，其中2种是肝癌。 1是模棱两可的。测试了32种化合物的RDS。 26例为阳性，包括8例胃腺癌致癌物和6例胃腺肿瘤促发剂。 4例为阴性，包括3种肝致癌物和胃刺激物;和2个模棱两可。测试了45种化合物的ODC。阳性37例，包括8例胃腺癌致癌物和1例胃腺肿瘤促进剂。 7文？阴性，包括3种肝致癌物;和一个模糊的世界人道主义峰会。所有腺胃癌致癌物和肿瘤促进剂在RDS和ODC中均呈阳性。对c-fos和c-myc表达有两种化合物。一个是腺胃癌致癌物，一个是腺胃肿瘤促进剂，两者均为阳性。此外，有2种化合物抑制了由肿瘤启动子NaCl诱导的RDS的增加，提示awkumor-promoter活性。因此，这些测定法可用于评估大鼠腺胃中的潜在的肿瘤引发和肿瘤促进活性。

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