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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Clastogenicity of methapyrilene hydrochloride in cultured Chinese hamster cells
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Clastogenicity of methapyrilene hydrochloride in cultured Chinese hamster cells

机译：盐酸甲萘丙啶在培养的中国仓鼠细胞中的致死性

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The antihistaminic agent methapyrilene hydrochloride (MPH, CAS No, 135-23-9) has been reported.as a potent rat hepatocarcinogen. However, neither the action mechanism nor mutagenicity of MPH have been clearly elucidated yet. Chromosomal aberration (CA) tests were performed with MPH in CHO-K1-BH4 and CHL cells, without a metabolic activation system. Isochromatid break-like aberrations were observed in metaphases of CHO-K1-BH4 cells treated with MPH. MPH induced CA more effectively at higher pH in equitoxicity base. In contrast to CHO-KJ-BH4 cells, typical chromatid type exchanges were observed in CHL cells treated with MPH. These results clearly support the results of other researchers that MPH induce chromosomal aberration and imply that MPH inducescancer in animal via other mechanisms than mere DNA damage or gene mutation which had been nearly proven to be negative by many researchers. It was suggested that pH variation might increase the sensitivity of CA tests for certain category of chemicalswith dissociation potential.
机译：抗组胺药盐酸甲萘丙啶（MPH，CAS No. 135-23-9）已被报道为强效大鼠肝致癌物。然而，尚未明确阐明MPH的作用机理或致突变性。在没有代谢激活系统的情况下，在CHO-K1-BH4和CHL细胞中用MPH进行了染色体畸变（CA）测试。在用MPH处理的CHO-K1-BH4细胞的中期观察到了异染色单体断裂样畸变。 MPH在较高pH下以等毒性碱更有效地诱导CA。与CHO-KJ-BH4细胞相反，在用MPH处理的CHL细胞中观察到典型的染色单体类型交换。这些结果清楚地支持了其他研究人员的研究结果，即MPH引起染色体畸变，并暗示MPH可以通过其他机制（不仅仅是DNA损伤或基因突变）通过其他机制在动物体内诱导扫描癌，这已被许多研究人员几乎证实为阴性。有人指出，pH值的变化可能会提高CA测试对某些具有解离潜力的化学药品的敏感性。

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