• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Induction of chromosome loss in yeast by combined treatment with neurotoxic hexacarbons and monoketones
【24h】

Induction of chromosome loss in yeast by combined treatment with neurotoxic hexacarbons and monoketones

机译：通过神经毒性六碳和单酮类化合物的联合处理诱导酵母中的染色体丢失

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The neurotoxic hexacarbon compounds n-hexane, 2-hexanone and 2,5-hexanedione were tested in combination with acetone and methyl ethyl ketone for the potential to induce chromosome loss in strain D61.M of Sacchdromyces cerevisiae. n-Hexane and 2-hexanone, alone or in combination, induced only marginally positive chromosome loss, whereas the metabolite and presumed proximal genetically active agent 2,5-hexanedione was strongly positive when tested alone and in combination. These, observations are discussed in relation to the reported potentiatipn of the neurotoxic effects of these hexacarbons when exposure results from combinations with other solvents, e.g., acetone and methyl ethy ketone. Treatments that result in neurotoxicity in experiment animalsand humans and those that result in chromosome loss in a yeast genetic test system may be correlated by their activity on a common intracelluiar target.
机译：测试了神经毒性六碳化合物正己烷，2-己酮和2,5-己二酮与丙酮和甲乙酮的组合，以诱导啤酒酵母D61.M菌株中染色体丢失的可能性。单独或组合使用正己烷和2-己酮仅会导致染色体边缘阳性，而单独或组合使用时代谢物和推测的近端遗传活性剂2,5-己二酮则呈强阳性。当与其他溶剂（例如丙酮和甲基乙酮）混合产生暴露时，这些六碳的神经毒性作用的报道的潜在增强作用将讨论这些观察结果。导致实验动物和人类神经毒性的治疗，以及导致酵母基因测试系统中染色体丢失的治疗，可能与其对共同细胞内靶标的活性相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号