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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Molecular and genetic toxicology of 1,3-butadiene
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Molecular and genetic toxicology of 1,3-butadiene

机译：1,3-丁二烯的分子和遗传毒理学

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During the last 9 years, there have been many studies published concerning the mutagenic potential of butadiene in mammalian systems, including alterations at the molecular level. Butadiene has tested positive in several mouse in vivo and in vitro assays, but has generally tested negative in rat studies. Most of these studies are cytogenetic and include positive data in mice for chromosomal aberrations, micronucleus formation, and sister chromatid exchanges. Butadiene also induces mutations in lung,spleen, and bone marrow of transgenic mice. The positive bone marrow cytogenetic and transgenic data may be significant in view of the increased lymphohematopoietic malignancies observed in mice and probably in humans. In addition, butadiene causes mutations in the K-ras protooncogene and in the p53 tumor suppressor gene in mouse studies. Mutations in these genes are associated with oncogenesis. in humans as well as in rodents. Also, positive mutagenicity data have been obtained in a pilot study of workers exposed to butadiene. Positive dominant lethal studies in rodents suggest that exposure to butadiene can result in germ cell mutation and heritable risk, These mutagenicity and molecular data suggest that butadiene is both a somatic and genn cell mutagen in mammals, possibly including humans.
机译：在过去的9年中，已经发表了许多关于丁二烯在哺乳动物系统中的诱变潜力的研究，包括分子水平的改变。丁二烯在几种小鼠体内和体外试验中均呈阳性，但在大鼠研究中通常呈阴性。这些研究大多数是细胞遗传学的，并且包括小鼠中染色体畸变，微核形成和姐妹染色单体交换的阳性数据。丁二烯还诱导转基因小鼠的肺，脾和骨髓中的突变。鉴于在小鼠乃至人类中观察到的淋巴造血系统恶性肿瘤增加，阳性的骨髓细胞遗传学和转基因数据可能是重要的。此外，在小鼠研究中，丁二烯会引起K-ras原癌基因和p53抑癌基因的突变。这些基因的突变与肿瘤发生有关。在人类和啮齿动物中。同样，在对丁二烯接触工人的初步研究中也获得了积极的致突变性数据。在啮齿动物中进行的主要显性致死研究表明，丁二烯暴露可导致生殖细胞突变和遗传风险。这些诱变性和分子数据表明，丁二烯在哺乳动物（包括人类）中既是体细胞诱变剂又是基因细胞诱变剂。

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