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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >THE INDUCTION OF DOMINANT SOMATIC MUTATIONS AT THE DLB-1 LOCUS
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THE INDUCTION OF DOMINANT SOMATIC MUTATIONS AT THE DLB-1 LOCUS

机译：在DLB-1位点诱导主要的体细胞突变

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In the small intestine of heterozygous mice (Dlb-1(b)/Dlb-1(a)), the Dlb-1(b) allele results in a stainable epithelium. The mutation or loss of the dominant Dlb-1(b) allele in a stem cell results in a non-staining ribbon of cells on a villus of the small intestine. To determine if dominant mutations resulting in the gain of staining - the induction of a Dlb-1(b)-like allele - could also be detected, we examined Dlb-1(a) homozygous mice (SWR) 2 weeks after a single treatment with 250 mg/kg ethylnitrosourea. Mutations to the dominant allele should appear as brown ribbons on unstained villi. Such ribbons were observed in the treated group but not in controls. The mutant frequency was low compared to the frequency of Dlb-1(a)-like mutations reported at the Dlb-1(b) allele in heterozygous mice.
机译：在杂合小鼠的小肠中（Dlb-1（b）/ Dlb-1（a）），Dlb-1（b）等位基因可染色上皮。干细胞中显性Dlb-1（b）等位基因的突变或丢失会导致小肠绒毛上的细胞出现非染色带。为了确定是否也可以检测到导致染色增加的显性突变-诱导Dlb-1（b）样等位基因-我们在单次治疗后2周检查了Dlb-1（a）纯合小鼠（SWR）含250 mg / kg乙基亚硝基脲。显性等位基因的突变应在未染色的绒毛上显示为褐色丝带。在治疗组中观察到这样的带，而在对照中则没有。与杂合小鼠中Dlb-1（b）等位基因报道的Dlb-1（a）样突变频率相比，该突变体频率低。

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