GENOTOXICITY ASSAY OF CHLORAL HYDRATE AND CHLOROPICRINE

Giller S; Lecurieux F; Gauthier L; Erb F; Marzin D

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GENOTOXICITY ASSAY OF CHLORAL HYDRATE AND CHLOROPICRINE

机译：氯水合物和氯吡啶的遗传毒性测定

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The chlorination by-products chloral hydrate and chloropicrine were assayed for genotoxicity in three short-term tests. Chloropicrine was 100-fold more potent than chloral in inducing mutations in strain TA100 of S. typhimurium (fluctuation test) and, at variance with chloral, was positive in the SOS chromotest using strain PQ37 of E. coli. On the other hand, only chloral caused a significant increase in the frequency of micronucleated erythrocytes following in vivo exposure of the amphibian Pleurodeles waltl newt larvae.

机译：在三个短期测试中，测定了氯化副产物水合氯醛和氯化苦参碱的遗传毒性。在诱导鼠伤寒沙门氏菌TA100菌株的突变（波动试验）中，氯霉素的效价比氯醛高100倍（与氯醛不同），在使用大肠杆菌PQ37菌株的SOS色谱测试中，氯霉素呈阳性。另一方面，在体内暴露两栖类侧耳侧耳幼虫后，仅氯醛引起微核红细胞频率的显着增加。

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《Mutation Research, C. Mutation Research Letters》 |1995年第4期|共6页
作者
Giller S; Lecurieux F; Gauthier L; Erb F; Marzin D;
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正文语种 eng
中图分类遗传学;
关键词
Chloral hydrate; Chloropicrine; Sos chromotest; Ames fluctuation test; Suspected spindle poisons; Disinfection by products; Aspergillus nidulans; Gas chromatography; Micronucleus assay; Human lymphocytes; Drinking water; Aneuploidy; Chemicals; Invitro;

机译：水合氯;氯霉素;Sos色谱;Ames波动试验;可疑纺锤体毒物;副产品消毒;构巢曲霉;气相色谱;微核测定;人类淋巴细胞;饮用水;非整倍性;化学药品;体外;

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1. GENOTOXICITY ASSAY OF CHLORAL HYDRATE AND CHLOROPICRINE [J] . Giller S, Lecurieux F, Gauthier L, Mutation Research, C. Mutation Research Letters . 1995,第4期

机译：氯水合物和氯吡啶的遗传毒性测定
2. The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate. [J] . Ikbal M, Tastekin A, Dogan H, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2004,第2期

机译：水合氯醛处理婴儿的淋巴细胞培养中的遗传毒性评估。
3. Comparison of rescue techniques for failed chloral hydrate sedation for magnetic resonance imaging scansadditional chloral hydrate vs intranasal dexmedetomidine [J] . Paediatric anaesthesia . 2016,第3期

机译：磁共振成像扫描失败的水合氯醛镇静抢救技术的比较其他水合氯醛与鼻内右美托咪定
4. High throughput genotoxicity assay of nanomaterials with single cell HaloChip assay [C] . Yong Qiao, Liyuan (Linda) Ma Society for Biomaterials annual meeting and exposition . 2015

机译：单细胞HaloChip分析法对纳米材料的高通量遗传毒性分析
5. Chromosome mutations induced by chloral hydrate in onion roots (Allium cepa). [D] . White, William W. E. 1998

机译：洋葱根中水合氯醛诱导的染色体突变（葱属）。
6. Efficacy of Chloral Hydrate-Hydroxyzine and Chloral Hydrate-Midazolam in Pediatric Magnetic Resonance Imaging Sedation [O] . Razieh FALLAH, Nafiseh FADAVI, Shekofah BEHDAD, 2014

机译：氯水合肼和咪达唑仑在小儿磁共振成像镇静中的作用
7. Comparative study of using thiopentone sodium –ketamine– chloral hydrate mixture and ketamine– chloral hydrate mixture as a general anesthetics in local pigeons [O] . Napeel Abdul Al-Rahman Khutair 2009

机译：硫代酮钠 - 丙氨酸水合物和氯胺酮水合物混合物用硫代酮钠 - 氯胺酮 - 当地鸽子的全麻麻醉剂

GENOTOXICITY ASSAY OF CHLORAL HYDRATE AND CHLOROPICRINE

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