CLASTOGENICITY OF ANTHRAQUINONES IN V79 AND IN THREE DERIVED CELL LINES EXPRESSING P450 ENZYMES

Simi S; Morelli S; Gervasi PG; Rainaldi G

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CLASTOGENICITY OF ANTHRAQUINONES IN V79 AND IN THREE DERIVED CELL LINES EXPRESSING P450 ENZYMES

机译：蒽醌在V79和3种表达P450酶的细胞系中的破伤性

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The clastogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The results have shown that chromosomal aberrations are modulated in similar manner both in parental and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.

机译：在仅表达还原途径酶的V79中国仓鼠细胞系中以及在转染并表达三种大鼠细胞色素P450（1A1、1A2、2B1）的三种衍生细胞系中研究了七个蒽醌的裂解能力。结果表明，亲本和转染的V79细胞系均以相似的方式调节染色体畸变，表明这些化合物的致胶原性不受细胞色素P450依赖性单加氧酶的介导。

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《Mutation Research, C. Mutation Research Letters》 |1995年第4期|共6页
作者
Simi S; Morelli S; Gervasi PG; Rainaldi G;
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正文语种 eng
中图分类遗传学;
关键词
Chromosomal aberration; Anthraquinone; Cytochrome p450; Chinese hamster cells; Metabolic activation; Hepatic microsomes; Emodin; Induction; Rats; Hydroxyanthraquinones; Carcinogenicity; Genotoxicity; Aberration;

机译：染色体畸变蒽醌细胞色素p450中国仓鼠细胞代谢激活肝微粒体大黄素诱导鼠羟基蒽醌致癌性遗传毒性畸变;

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1. 细胞色素P450花生四烯酸表氧化酶在人肿瘤组织及肿瘤细胞系中的特异性表达 [J] . 蒋建刚, 付向宁, 陈春莲, 癌症（英文版） . 2009,第002期
2. Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes. [J] . Simi S, Morelli S, Gervasi PG, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1995,第3a4期

机译：蒽醌在V79和表达P450酶的三个衍生细胞系中的致死性。
3. Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1. [J] . Bernauer U, Glatt H, Heinrich-Hirsch B, Alternatives to laboratory animals: ATLA . 2003,第1期

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4. DNA adduct formation by 7H-dibenzo(c,g)carbazole and its tissue- and organ-specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes. [J] . Gabelova A, Binkova B, Valovicova Z, Environmental and molecular mutagenesis. . 2004,第5期

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5. MODULATION OF CYTOCHROME P450 ENZYME FUNCTION AND EXPRESSION BY PIPERINE IN CELLULOSIC SPONGE SYSTEM [C] . W Zhang, R Sakban, B Nugraha, World biomaterials congress . 2012

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6. Molecular analysis of matrix metalloproteinases and RECK expression in breast cancer cell lines derived from African-American and Caucasian women [D] . Mason, Jacquline Annette 2006

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8. Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1 [O] . W. R. Fields 1999

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9. Identical Expression of Cell Surface Membrane Antigens on Two Parent and Eighteen Cloned Cell Lines Derived from Two Different Neuroblastoma Metastases of the Same Patient [R] . Sugimoto, T., Sawada, T., Matsumura, T., 1986

机译：细胞表面膜抗原在同一患者的两种不同神经母细胞瘤转移的两个父母和18个克隆细胞系中的相同表达

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CLASTOGENICITY OF ANTHRAQUINONES IN V79 AND IN THREE DERIVED CELL LINES EXPRESSING P450 ENZYMES

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