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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >DETECTION OF MUTAGENICITY OF DIPHENYL ETHER HERBICIDES IN SALMONELLA TYPHIMURIUM YG1026 AND YG1021
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DETECTION OF MUTAGENICITY OF DIPHENYL ETHER HERBICIDES IN SALMONELLA TYPHIMURIUM YG1026 AND YG1021

机译：鼠伤寒沙门氏菌YG1026和YG1021中二苯醚除草剂的致突变性检测

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摘要

Three kinds of diphenyl ether herbicides, 4-nitrophenyl 2,4,6-trichlorophenyl ether (CNP, chlornitrofen), 2,4-dichlorophenyl 3-methoxy-4-nitrophenyl ether (chlomethoxynil) and 2,4-dichlorophenyl 3-methoxycarbonyl-4-nitrophenyl ether (bifenox), were tested for mutagenicity in Salmonella typhimurium YG1026 and YG1021, which have high nitroreductase activity, and also in S. typhimurium TA100 and TA98. CNP and chlomethoxynil showed mutagenicity in S. typhimurium YG1026, without S9 mix, inducing 50 and 304 revertants per mu g These mutagenicities were suppressed by the addition of S9 mix. CNP and chlomethoxynil were also mutagenic to YG1021 with and without S9 mix, and their mutagenicities were lower than those to YG1026. On the other hand, bifenox was mutagenic to YG1026 only with S9 mix, inducing 3.0 revertants per mu g. These three herbicides showed no mutagenicity in S. typhimurium TA100 and TA98 either with or without S9 mix.
机译：三种二苯醚除草剂：4-硝基苯基2,4,6-三氯苯基醚（CNP，氯硝基苯），2,4-二氯苯基3-甲氧基-4-硝基苯醚（氯甲氧基）和2,4-二氯苯基3-甲氧基羰基-在具有高硝基还原酶活性的鼠伤寒沙门氏菌YG1026和YG1021以及鼠伤寒沙门氏菌TA100和TA98中测试了4-硝基苯醚（bifenox）的致突变性。在没有S9混合物的情况下，CNP和氯甲氧基腈在鼠伤寒沙门氏菌YG1026中显示出致突变性，每μg诱导50和304个回复株。通过添加S9混合物可以抑制这些致突变性。在有和没有S9混合液的情况下，CNP和氯甲氧基对YG1021也具有致突变性，其致突变性低于对YG1026的致突变性。另一方面，仅使用S9混合物，联苯醚才对YG1026有诱变作用，每μg诱导产生3.0个还原酶。这三种除草剂在鼠伤寒沙门氏菌TA100和TA98中，无论是否混有S9都没有致突变性。

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