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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >EFFECT OF DIETARY COMPONENTS ON HPRT MUTANT FREQUENCIES IN HUMAN T-LYMPHOCYTES
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EFFECT OF DIETARY COMPONENTS ON HPRT MUTANT FREQUENCIES IN HUMAN T-LYMPHOCYTES

机译：饮食成分对人T淋巴细胞HPRT突变频率的影响

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摘要

The 6-thioguanine resistance (TG(r)) assay in human T-lymphocytes, which detects mutations at the hprt locus, identifies exposures to environmental mutagens. However, the ability of this assay to detect small increases in mutation rates is limited by the broad range of mutant frequencies (Mf) in healthy individuals. While subject age, lymphocyte cloning efficiency, and cigarette smoking history have been shown to influence the Mf, these factors account for only a portion of the variability in the Mf in human populations. To investigate the influence of dietary differences on hprt Mf, 70 women with breast masses were asked to complete a nutritional questionnaire and submit a peripheral blood sample for a TG(r) assay. Multivariate analyses, adjusted for age, cloning efficiency and total caloric intake, showed significant positive correlations between vitamin A and iron and lnMf (p = 0.03), and a negative correlation between total fat and lnMf (p = 0.004). Positive correlations between dietary fiber and copper and lnMf, and a negative correlation between alcohol and lnMf were of borderline significance (0.05 less than or equal to p less than or equal to 0.07). These results suggest that nutritional components may modulate the hprt Mf Dietary differences may account for a part of the variability observed in hprt Mf in human populations.
机译：检测人hprt基因座突变的人T淋巴细胞中的6硫鸟嘌呤抗性（TG（r））分析可确定环境诱变剂的暴露情况。但是，该检测方法检测突变率的小幅提高的能力受到健康个体中突变频率（Mf）的广泛限制。尽管已证明受试者年龄，淋巴细胞克隆效率和吸烟史会影响Mf，但这些因素仅占人群Mf变异性的一部分。为了调查饮食差异对hprt Mf的影响，要求70名有乳房肿块的妇女填写营养调查表并提交外周血样本进行TG（r）分析。经过年龄，克隆效率和总热量摄入调整后的多元分析显示，维生素A与铁和lnMf之间呈显着正相关（p = 0.03），而总脂肪与lnMf之间呈负相关（p = 0.004）。膳食纤维与铜和lnMf之间呈正相关，而酒精与lnMf之间呈负相关（0.05小于或等于p小于或等于0.07）。这些结果表明，营养成分可能会调节hprt Mf饮食差异可能解释了人类人群hprt Mf中观察到的变异性的一部分。

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