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SCE analysis in human lymphocytes of a Spanish control population

机译：西班牙对照人群的人淋巴细胞中的SCE分析

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摘要

SCE (siSter-ohromatJd exchanges), HFC (high frequency cells) and PRI (proliferative rate index) were studied in the peripheral blood lymphocytes of 154 healthy male volunteers, from Barcelona (Spain). SCE, HFC and PRI variability between and/or withinindividuals was estimated by means of a mixed linear model. This model allows a determination of the relationship between confounding factors (demographics, life style, work exposure and medical history) and the cytogcnetic and cytokinetic parameters analyzed. The results obtained indicate the existence of an important intra-indtvidual heterogeneity in SCE rates, as well as in HFC and PRI values. Although age did not seem to affect either the SCE frequency or the HFC percentage, it showed a significantpositive association with the presence of cells with higher SCE frequencies, With respect to the confounding factors, only cigarette smoking increased the SCE rates and the HFC values. On the other hand, PRI mean showed significant differences dependenton age and was inversely correlated with alcohol consumption and X-ray exposure.
机译：在来自西班牙巴塞罗那的154名健康男性志愿者的外周血淋巴细胞中研究了SCE（同位异位交换），HFC（高频细胞）和PRI（增殖率指数）。通过混合线性模型估计个体之间和/或内部的SCE，HFC和PRI变异性。该模型可以确定混杂因素（人口统计学，生活方式，工作经历和病史）与所分析的细胞动力学和细胞动力学参数之间的关系。获得的结果表明，在SCE率以及HFC和PRI值中，存在重要的企业内部异质性。尽管年龄似乎并没有影响SCE频率或HFC百分比，但它与存在较高SCE频率的细胞存在显着的正相关性。就混杂因素而言，仅吸烟增加了SCE频率和HFC值。另一方面，PRI平均值显示出明显的差异，取决于年龄，并且与饮酒量和X射线暴露呈负相关。

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