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首页> 外文期刊>Mutation Research, E. Environmental Mutagenesis and Related Subjects >COMPARATIVE STUDY ON CYTOGENETIC DAMAGE INDUCED BY HOMO-AZA-STEROIDAL ESTERS IN HUMAN LYMPHOCYTES
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COMPARATIVE STUDY ON CYTOGENETIC DAMAGE INDUCED BY HOMO-AZA-STEROIDAL ESTERS IN HUMAN LYMPHOCYTES

机译：同型氮杂-甾体酯类对人淋巴细胞诱导的细胞遗传损伤的比较研究

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摘要

The effect of P[N,N-bis(2-chloroethyl)amino]phenylacetate esters of 3 beta-hydroxy-N-methyl-17 alpha-aza-D-homo-5 alpha-androstan-17-one (compound 3) and 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstane (compound 2) on sister-chromatid exchange (SCE) frequencies and on human lymphocytes proliferation kinetics was studied. The results are compared with those of the P[N,N-bis(2-chloroethyl)amino]phenylacetate esters of 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstan-17-one (compound 1). All compounds were found to be active in inducing markedly increased SCE rates and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumour activity of these compounds was observed.
机译：3个β-羟基-N-甲基-17α-氮杂-D-homo-5α-雄甾烷17-一的P [N，N-双（2-氯乙基）氨基]苯乙酸酯的作用（化合物3）研究了3个β-羟基-17α-氮杂-D-homo-5α-雄甾烷（化合物2）对姐妹染色单体交换（SCE）频率和人淋巴细胞增殖动力学的影响。将结果与3个β-羟基-17α-氮杂-D-homo-5α-雄甾烷17-一（化合物1的P [N，N-双（2-氯乙基）氨基]苯基乙酸酯）。发现所有化合物都具有诱导SCE率和细胞分裂延迟显着增加的活性。观察到了SCE诱导的效力，细胞分裂延迟的有效性与这些化合物先前建立的抗肿瘤活性之间的相关性。

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