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首页> 外文期刊>Muscle and Nerve >Properties of extensor digitorum longus muscle and skinned fibers from adult and aged male and female Actn3 knockout mice.
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Properties of extensor digitorum longus muscle and skinned fibers from adult and aged male and female Actn3 knockout mice.

机译：成年和成年雄性和雌性Actn3基因敲除小鼠的指趾伸肌和皮肤纤维的特性。

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摘要

Absence of alpha-actinin-3, encoded by the ACTN3 "speed gene," is associated with poorer sprinting performance in athletes and a slowing of relaxation in fast-twitch muscles of Actn3 knockout (KO) mice. Our first aim was to investigate, at the individual-fiber level, possible mechanisms for this slowed relaxation. Our second aim was to characterize the contractile properties of whole extensor digitorum longus (EDL) muscles from KO mice by age and gender. We examined caffeine-induced Ca(2+) release in mechanically skinned EDL fibers from KO mice, and measured isolated whole EDL contractile properties. The sarcoplasmic reticulum of KO muscle fibers loaded Ca(2+) more slowly than that of wild-types (WTs). Whole KO EDL muscles had longer twitch and tetanus relaxation times than WTs, and reduced mass and cross-sectional area. These effects occurred in both male and female mice, but they diminished with age. These changes in KO muscles and fibers help to explain the effects of alpha-actinin-3 deficiency observed in athletes.
机译：由ACTN3“速度基因”编码的α-actinin-3的缺乏与运动员的冲刺表现较差以及Actn3基因敲除（KO）小鼠的快速抽搐肌肉的松弛速度减慢有关。我们的首要目标是在单纤维水平上研究这种缓慢松弛的可能机制。我们的第二个目标是按年龄和性别表征来自KO小鼠的整个指趾长伸肌（EDL）肌肉的收缩特性。我们检查了咖啡因诱发的Ca（2+）释放从KO小鼠的机械皮肤EDL纤维，并测量了分离的整个EDL收缩特性。 KO肌纤维的肌质网加载Ca（2+）比野生型（WTs）慢。整个KO EDL肌肉的抽搐和破伤风松弛时间均比野生型更长，并且质量和横截面积减小。这些影响在雄性和雌性小鼠中均发生，但随着年龄的增长而减弱。 KO肌肉和纤维的这些变化有助于解释运动员中观察到的α-actinin-3缺乏症的影响。

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