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首页> 外文期刊>Cancer: A Journal of the American Cancer Society >Oncologic outcomes of open conservation laryngectomy for radiorecurrent laryngeal carcinoma: a systematic review and meta-analysis of english-language literature.
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Oncologic outcomes of open conservation laryngectomy for radiorecurrent laryngeal carcinoma: a systematic review and meta-analysis of english-language literature.

机译：开放性保留喉切除术治疗放射性复发性喉癌的肿瘤学结果：英语文献的系统评价和荟萃分析。

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BACKGROUND: The role of open conservation (partial) laryngeal surgery in radiorecurrent laryngeal cancers is unclear, and the procedure is not widely accepted or practiced. The objective of this review was to assess the oncologic and functional outcomes of partial laryngectomy in radiorecurrent tumors of the larynx reported in the literature. METHODS: The systematic review was performed using independently developed search strategies and included Medline, Embase, Zetoc, conference proceedings, and, when appropriate, a manual search. Inclusion criteria for the articles were set a priori. All included articles were subjected to quality assessment. Pooled estimates of local control at 24 months and of disease-free and overall survival rates were calculated using both a fixed-effects model (inverse square) and a random-effects model (DerSimonian-Laird). RESULTS: The search identified 401 publications, of which 26 studies satisfied all inclusion criteria. Ten studies had a quality score >/=6 (good), and 16 had a score of 4 or 5 (fair). The pooled estimates of oncologic outcomes using the random-effects model were as follows: The local control rate at 24 months for 560 patients was 86.9% (95% CI, 84%-89.5%), the disease-free survival rate for 352 patients was 91.2% (95% CI, 88.2%-93.9%), and the overall survival rate for 360 patients was 83.1% (95% CI, 79.1%-86.7%). Decannulation of tracheostomy occurred in 95.1% (95% CI, 92.6%-97.2%) of the patients who were analyzed (n = 315), whereas the pooled mean larynx preservation rate was 83.9% (95% CI, 80.7%-87%; n = 502) CONCLUSIONS: The current results indicated that open partial laryngectomies are oncologically sound procedures in the salvage setting and have a high larynx preservation rate.
机译：背景：开放性（部分）喉癌手术在放射性复发性喉癌中的作用尚不清楚，并且该手术尚未得到广泛接受或实践。这篇综述的目的是评估文献报道的喉部放射性复发性肿瘤部分喉切除术的肿瘤学和功能结局。方法：系统评价是使用独立开发的检索策略进行的，包括Medline，Embase，Zetoc，会议记录以及在适当时进行的人工检索。文章的纳入标准是事先确定的。所有纳入的物品均经过质量评估。使用固定效应模型（平方反比）和随机效应模型（DerSimonian-Laird），计算24个月局部控制以及无病生存率和总生存率的汇总估计值。结果：搜索确定401出版物，其中26个研究满足所有纳入标准。十项研究的质量得分> / = 6（好），而十六项质量得分为4或5（一般）。使用随机效应模型汇总的肿瘤学结局评估如下：560例患者在24个月时的局部控制率为86.9％（95％CI，84％-89.5％），352例患者的无病生存率为91.2％（95％CI，88.2％-93.9％），360名患者的总生存率为83.1％（95％CI，79.1％-86.7％）。在被分析的患者（n = 315）中，气管切开术发生无环切术的比例为95.1％（95％CI，92.6％-97.2％），而合并喉平均保存率为83.9％（95％CI，80.7％-87％） ; n = 502）结论：目前的结果表明，开放性部分喉切除术在挽救环境中是肿瘤学上合理的手术，并且具有较高的喉部保存率。

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