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首页> 外文期刊>Muscle and Nerve >MATTERS OF FIBER SIZE AND MYONUCLEAR DOMAIN: DOES SIZE MATTER MORE THAN AGE?
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MATTERS OF FIBER SIZE AND MYONUCLEAR DOMAIN: DOES SIZE MATTER MORE THAN AGE?

机译：纤维尺寸和肌无力域的问题：尺寸比年龄重要吗？

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Introduction: The relationship between fiber size and myonuclear content is poorly understood. Methods: Biopsy cross-sections from young and old trained and untrained healthy individuals were analyzed for fiber area and myonuclei, and 2 fiber-size-dependent cluster analyses were performed. Results: When comparing fibers of similar size, no effect of training or age was found for myonuclear domain. There was a linear relationship between fiber area and myonuclei per fiber (r = 0.99; P < 0.001) and a non-linear relationship between fiber area and domain (r = 0.97-0.99; P < 0.0001), with a markedly smaller domain in fibers < 3,000 mu m(2). A higher proportion of type II fibers < 3,000 mu m(2) was observed in the old subjects. Conclusions: These findings suggest that age-related reductions in myonuclear domain size could be explained by the greater proportion of small fibers. The data also highlight the usefulness of determining fiber-size-based clusters for gaining mechanistic insight into the relationship between skeletal muscle fiber size and myonuclear content.
机译：简介：人们对纤维大小与肌核含量之间的关系了解甚少。方法：对经过训练的和未经过训练的健康个体的活检横截面进行纤维面积和肌核的分析，并进行了两次纤维大小依赖性聚类分析。结果：当比较相似大小的纤维时，未发现肌核区域受训练或年龄的影响。纤维面积与每根纤维的肌核之间存在线性关系（r = 0.99; P <0.001），纤维面积与区域之间呈非线性关系（r = 0.97-0.99; P <0.0001），其中纤维<3,000微米（2）。在老年受试者中观察到比例更高的<3,000μm（2）的II型纤维。结论：这些发现表明，与年龄相关的肌核结构域尺寸的减小可以由小纤维的更大比例来解释。数据还强调了确定基于纤维大小的聚类的有用性，以获取对骨骼肌纤维大小与肌核含量之间关系的机械理解。

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