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首页> 外文期刊>Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases >Once daily treatment with terbinafine 1% cream (Lamisil) for one week is effective in the treatment of tinea corporis and cruris. A placebo-controlled study.
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Once daily treatment with terbinafine 1% cream (Lamisil) for one week is effective in the treatment of tinea corporis and cruris. A placebo-controlled study.

机译：每天使用1％特比萘芬1％乳膏（Lamisil）每天治疗一次，有效治疗体癣和十字花科。安慰剂对照研究。

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摘要

Duration of therapy is an important factor in determining patients' compliance in dermatomycosis. Terbinafine (Lamisil) is an allylamine antifungal agent. Its fungicidal properties against dermatophytes should allow physicians to reduce treatment duration without affecting the cure rate. This study was carried out to determine the efficacy and tolerability of terbinafine 1% cream, applied once daily for 7 days, in adult patients with tinea corporis/cruris. In a multicentre, randomized, double-blind, parallel-group study, patients with a clinical diagnosis of tinea corporis/cruris confirmed by microscopy and culture received treatment with either terbinafine 1% cream (n = 57) or placebo cream (n = 60). The patients applied the cream once daily for 7 days, and were then observed for a further 7 weeks. The efficacy was assessed at the end of the study by comparing the rates of mycological cure in the two treatment groups. Total clinical signs and symptoms scores, clinical response, and overall treatment efficacy were also measured and compared between the two groups. A 7-day once-daily course of terbinafine was significantly more effective than placebo in achieving and maintaining mycological cure (84.2 versus 23.3%, P< 0.001). Terbinafine was also significantly more effective than placebo in terms of clinical response, reduction in signs and symptoms scores, and overall efficacy. The short treatment regimen and the sustained high cure rate should contribute to making terbinafine a valuable treatment option in tinea corporis/cruris.
机译：治疗的持续时间是确定患者对皮肤癣菌病依从性的重要因素。特比萘芬（Lamisil）是一种烯丙胺抗真菌剂。它对皮肤真菌的杀菌性能应使医生缩短治疗时间而不会影响治愈率。这项研究的目的是确定在体癣/瘙痒症的成年患者中每天1次连续7天使用特比萘芬1％乳膏的功效和耐受性。在一项多中心，随机，双盲，平行组研究中，经显微镜和培养证实患有体癣//的临床诊断的患者接受特比萘芬1％乳膏（n = 57）或安慰剂乳膏（n = 60）的治疗）。患者每天使用一次乳霜，持续7天，然后再观察7周。在研究结束时通过比较两个治疗组的真菌学治愈率评估疗效。还测量了两组的总临床体征和症状评分，临床反应和总体治疗效果。特比萘芬每天7天一次的疗程在实现和维持真菌学治愈方面比安慰剂有效得多（84.2对23.3％，P <0.001）。在临床反应，体征和症状评分降低以及总体疗效方面，特比萘芬也比安慰剂有效得多。短的治疗方案和持续的高治愈率应有助于使特比萘芬成为体癣/ cr癣的有价值的治疗选择。

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