GENOTOXICITY EVALUATION OF ESTRADIOL

Dhillon VS; Dhillon IK

首页> 外文期刊>Mutation research. Genetic toxicology testing >GENOTOXICITY EVALUATION OF ESTRADIOL

【24h】

GENOTOXICITY EVALUATION OF ESTRADIOL

机译：雌二醇的遗传毒性评价

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Genotoxic evaluation of estradiol, a commonly used estrogen, was undertaken using various short-term in vitro and in vivo assays. The clastogenic potential of estradiol was evident from the chromosome aberrations and sister chromatid exchanges induced by it both without and with metabolic activation in cultured human lymphocytes and also from the increased frequencies of micronuclei formation and sister chromatid exchanges in mice. However in the Ames Salmonella assay, both without and with S9 mix, and also in the host-mediated assay, estradiol was unable to cause a significant increase/decrease in the His(+) revertants/plate.

机译：雌二醇（一种常用的雌激素）的遗传毒性评估是通过各种短期的体外和体内试验进行的。雌二醇的致胶化潜力从其在培养的人淋巴细胞中不经代谢活化引起的染色体畸变和姊妹染色单体交换中得到证实，还通过小鼠微核形成和姊妹染色单体交换频率的增加而明显。但是，在Ames沙门氏菌测定中，无论是否使用S9混合液，以及在宿主介导的测定中，雌二醇均无法导致His（+）还原子/平板的显着增加/减少。

著录项

来源
《Mutation research. Genetic toxicology testing》 |1995年第2期|共9页
作者
Dhillon VS; Dhillon IK;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类遗传学;
关键词
Ames test; Human lymphocyte; Sister chromatid exchange (sce); Sister chromatid exchanges; Host mediated assay; Salmonella typhimurium; Mutagenicity test; Diethylstilbestrol; Induction; Invitro; Cells; Derivatives; Carcinogens;

机译：Ames试验;人类淋巴细胞;姐妹染色单体交换（sce）;姐妹染色单体交换;宿主介导的测定;鼠伤寒沙门氏菌;致突变性试验;己烯雌酚;诱导;体外;细胞;衍生物;致癌物;

相似文献

外文文献
中文文献
专利

1. GENOTOXICITY EVALUATION OF ESTRADIOL [J] . Dhillon VS, Dhillon IK Mutation research. Genetic toxicology testing . 1995,第1a2期

机译：雌二醇的遗传毒性评价
2. 17 beta-Estradiol induces cyto-genotoxicity on blood cells of common carp (Cyprinus carpio) [J] . Orozco-Hernandez Luis, Andrea Gutierrez-Gomez Adriana, SanJuan-Reyes Nely, Chemosphere . 2018,第jana期

机译：17β-雌二醇诱导鲤鱼血细胞的细胞遗传毒性
3. Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[ a ]pyrene and expression of this enzyme in rats [J] . Marie Stiborová, Helena Dra?ínská, Lucie Bo?ek-Dohalská, Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2018,第期

机译：暴露于内分泌破坏剂17Alpha-乙烯烯醇二醇和雌二醇影响细胞色素P450 1A1介导的苯并[a]芘的遗传毒性和该酶在大鼠中的表达
4. An evaluation of a modified slow cool cryopreservtion technqiue and the efficacy of a graduated estradiol regimen vs. Natural cycles on pregnancy rates following frozen embryo transfer [C] . Choe JK, Check JH World Congress on In Vitro Fertilization . 2011

机译：改性缓慢冷冻冷冻体系的评价及毕业雌二醇方案与自然循环对冷冻胚胎转移后妊娠率的疗效
5. Design and synthesis of molecular probes to modulate cell membrane permeation: I. Design, synthesis, and biological evaluation of novel chicoric acid analogues as inhibitors of HIV-1 integrase. II. Design, synthesis, and biological evaluation of novel estradiol analogues targeting the membrane estrogen receptor. [D] . Charvat, Trevor Thomas. 2004

机译：设计和合成的分子探针，可调节细胞膜的渗透性：I.设计，合成和生物评价作为抗HIV-1整合酶抑制剂的新型菊苣酸类似物。二。针对膜雌激素受体的新型雌二醇类似物的设计，合成和生物学评估。
6. Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzoapyrene and expression of this enzyme in rats [O] . Marie Stiborová, Helena Dračínská, Lucie Bořek-Dohalská, -1

机译：暴露于内分泌干扰物17α-炔雌醇和雌二醇影响细胞色素P450 1A1介导的苯并a re的遗传毒性和该酶在大鼠中的表达
7. Is Estradiol a Genotoxic Mutagenic Carcinogen?1 [O] . Joachim G. Liehr 2000

机译：是雌二醇是一种遗传毒性诱变致癌致癌致癌致癌致癌致癌物

GENOTOXICITY EVALUATION OF ESTRADIOL

摘要

著录项

相似文献

相关主题

期刊订阅