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首页> 外文期刊>Mutation Research. Reviews in Mutation Research >Formation of chromosome aberrations: insights from FISH
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Formation of chromosome aberrations: insights from FISH

机译：染色体畸变的形成：FISH的见解

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摘要

Most of the mutagettic and carcinogenic agents induce chromosome aberrations in vivo and in vitro. Conventional solid staining (such as Giemsa) has been employed to evaluate the frequencies and types of spontaneous and induced chromosomal aberrations. Recently, molecular cytogenetic techniques such as fluorescence in situ hybridization (FISH) using chromosome specific or chromosome region-specific DNA libraries have become available, which have increased the resolution of the detection of aberrations. This has lead to a better understanding on the mechanisms of formation of chromosome aberrations, especially following treatment with ionizing radiation. The present paper reviews briefly the results obtained using FISH technique both from basic and applied studies.
机译：大多数诱变剂和致癌剂会在体内和体外诱导染色体畸变。常规的固体染色（如Giemsa）已用于评估自发和诱发染色体畸变的频率和类型。近来，已经获得了使用染色体特异性或染色体区域特异性DNA库的分子细胞遗传技术，例如荧光原位杂交（FISH），这增加了畸变检测的分辨率。这使人们对染色体畸变的形成机理有了更好的了解，尤其是在电离辐射处理之后。本文简要回顾了使用FISH技术从基础研究和应用研究中获得的结果。

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