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首页> 外文期刊>Mutation Research. Reviews in Mutation Research >DNA damage in organs of female and male mice exposed to nonylphenol, as a single agent or in combination with ionizing irradiation: A comet assay study
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DNA damage in organs of female and male mice exposed to nonylphenol, as a single agent or in combination with ionizing irradiation: A comet assay study

机译：暴露于壬基酚的雌性和雄性小鼠器官中的DNA损伤，作为一种单一试剂或与电离辐射结合使用：一项彗星试验研究

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摘要

The effect of nonylphenol (NP; either alone or in combination with ionizing radiation) on the induction of DNA strand breaks in mouse somatic cells has been examined. Male and female mice were repeatedly irradiated with X-rays (0.05 or 0.10 Gy), injected with NP (25 or 50 mg/kg bw), or both (0.05 Gy + 25 mg/kg bw NP or 0.10Gy +50 mg/kg bw NP), for 2 weeks, 5 days/week. Liver, spleen, femora, lungs and kidneys were removed from each animal for the comet assay. NP-induced DNA damage differed, depending on organ and sex. In male mice, NP induced damage in all organs examined; in females, only the kidneys were affected. The effect of irradiation alone was similar in females and males. Combined exposure of males to 0.05 Gy + 25 mg/kg bw NP significantly reduced the level of DNA strand breaks, compared to the controls and to 25 mg/kg bw NP alone, in the majority of organs. The higher doses significantly increased damage to DNA in all organs examined. Combined exposure of females to low doses of both agents significantly enhanced damage to DNA in bone marrow lymphocytes and in cells of the liver and kidneys, compared to controls. At 0.10Gy + 50mg/kg bw NP, DNA damage was increased in organs except liver and spleen. Although NP alone may not be mutagenic in female mice, its co-administration with irradiation may increase DNA damage in some organs. In contrast, in male mice, damage was reduced after combined irradiation-NP exposure, compared to NP alone.
机译：已经研究了壬基酚（NP;单独或与电离辐射组合）对小鼠体细胞DNA链断裂的诱导作用。雄性和雌性小鼠反复用X射线（0.05或0.10 Gy）照射，注射NP（25或50 mg / kg bw）或同时注射两种（0.05 Gy + 25 mg / kg bw NP或0.10Gy +50 mg / kg bw NP），持续2周，每周5天。从每只动物中取出肝脏，脾脏，股骨，肺和肾脏进行彗星测定。 NP诱导的DNA损伤因器官和性别而异。在雄性小鼠中，NP诱导了所有检查器官的损伤。在女性中，仅肾脏受到了影响。单独照射对女性和男性的影响相似。与对照组相比，雄性小鼠在0.05 Gy + 25 mg / kg bw NP中的联合暴露显着降低了DNA链断裂的水平，在大多数器官中单独暴露于25 mg / kg bw NP。较高的剂量显着增加了所有检查器官对DNA的损伤。与对照组相比，女性在低剂量的两种药物中的联合暴露显着增强了对骨髓淋巴细胞以及肝和肾细胞中DNA的损伤。在0.10Gy + 50mg / kg bw NP下，除肝脏和脾脏外器官的DNA损伤增加。尽管单独的NP可能不会在雌性小鼠中诱变，但将其与放射线并用可能会增加某些器官的DNA损伤。相反，在雄性小鼠中，与单独使用NP相比，在联合使用NP辐照后损伤减少了。

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