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首页> 外文期刊>Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects >Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Grou
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Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Grou

机译：使用年轻大鼠评估使用9种化学物质进行的肝和外周血微核分析的评估。微核试验合作研究小组（CSGMT）/日本环境诱变学会（JEMS）-哺乳动物致突变性研究组的研究

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We conducted simultaneous liver and peripheral blood micronucleus assays in young rats with seven rodent hepatocarcinogens-4,4'-methylenedianiline (MDA), quinoline, o-toluidine, 4-chloro-o-phenylenediamine (CPDA), dimethylnitrosamine (DMN), p-dimethylaminoazobenzene (DAB), and di(2-ethylhexyl)phthalate (DEHP)-and two mutagenic chemicals-kojic acid and methylmethanesulfonate (MMS). Quinoline, DMN, and DAB were positive in the liver assay, while o-toluidine, kojic acid, DAB, and MMS were positive in the peripheral blood assay. o-Toluidine, kojic acid, and DAB are reportedly negative in mouse bone marrow micronucleus assays, indicating a species difference. Our results revealed a correlation between micronucleus induction in hepatocytes and hepatocarcinogenicity. This technique can be useful for the detection of micronucleus-inducing chemicals that require metabolic activation, and it enables simultaneous comparison of the micronucleus-inducing potential of chemicals in the liver and peripheral blood in the same individual.
机译：我们在幼鼠中对7种啮齿类肝癌致癌物-4,4'-亚甲基二苯胺（MDA），喹啉，邻甲苯胺，4-氯-邻苯二胺（CPDA），二甲基亚硝胺（DMN），p进行了同时的肝和外周血微核测定-二甲基氨基偶氮苯（DAB）和邻苯二甲酸二（2-乙基己基）酯（DEHP）-以及两种诱变化学品-曲酸和甲磺酸甲酯（MMS）。喹啉，DMN和DAB在肝脏测定中呈阳性，而邻甲苯胺，曲酸，DAB和MMS在外周血测定中呈阳性。据报道，在小鼠骨髓微核试验中，邻甲苯胺，曲酸和DAB均为阴性，表明物种差异。我们的研究结果揭示了肝细胞中微核诱导与肝致癌性之间的相关性。该技术可用于检测需要代谢激活的诱导微核的化学物质，并且可以同时比较同一个人在肝脏和外周血中诱导微核的化学物质的潜力。

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