THE GENOTOXICITY PROFILE OF ATORVASTATIN, A NEW DRUG IN THE TREATMENT OF HYPERCHOLESTEROLEMIA

Ciaravino V; Kropko ML; Rothwell CE; Hovey CA; Theiss JC

首页> 外文期刊>Mutation research. Genetic toxicology testing >THE GENOTOXICITY PROFILE OF ATORVASTATIN, A NEW DRUG IN THE TREATMENT OF HYPERCHOLESTEROLEMIA

【24h】

THE GENOTOXICITY PROFILE OF ATORVASTATIN, A NEW DRUG IN THE TREATMENT OF HYPERCHOLESTEROLEMIA

机译：阿托伐他汀的基因毒性谱图，一种治疗胆固醇过高的新药

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

While HMG-CoA reductase inhibitors such as fluvastatin, lovastatin, pravastatin and simvastatin demonstrate lack of in vitro and in vivo mutagenicity and clastogenicity in bacterial and mammalian cells, long term rodent carcinogenicity studies resulted in an increased incidence in neoplasms at high doses. These effects may be attributable to an exaggeration of the desired biochemical effect of the drug and/or a tumor promoting effect.

机译：尽管HMG-CoA还原酶抑制剂（例如fluvastatin，lovastatin，pravastatin和simvastatin）在细菌和哺乳动物细胞中缺乏体外和体内的致突变性和致突变性，但长期的啮齿类动物致癌性研究导致高剂量肿瘤的发病率增加。这些作用可能归因于药物所需的生物化学作用和/或肿瘤促进作用的夸大。

著录项

来源
《Mutation research. Genetic toxicology testing》 |1995年第3期|共13页
作者
Ciaravino V; Kropko ML; Rothwell CE; Hovey CA; Theiss JC;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类遗传学;
关键词
Gene tox program; Assays; Mutagenicity; Micronuclei; Lovastatin; Reversion;

机译：基因毒程序;分析;致突变性;微核;洛伐他汀;回复;

相似文献

外文文献
中文文献
专利

1. THE GENOTOXICITY PROFILE OF ATORVASTATIN, A NEW DRUG IN THE TREATMENT OF HYPERCHOLESTEROLEMIA [J] . Ciaravino V, Kropko ML, Rothwell CE, Mutation research. Genetic toxicology testing . 1995,第2a3期

机译：阿托伐他汀的基因毒性谱图，一种治疗胆固醇过高的新药
2. Changes in ultracentrifugally separated plasma lipoprotein subfractions in patients with polygenic hypercholesterolemia, familial combined hyperlipoproteinemia, and familial hypercholesterolemia after treatment with atorvastatin [J] . Homma Koichiro, Homma Yasuhiko, Yoshida Tadashi, Journal of clinical lipidology . 2015,第2期

机译：阿托伐他汀治疗后多基因高胆固醇血症，家族性合并高脂蛋白血症和家族性高胆固醇血症患者超速离心分离血浆脂蛋白亚组分的变化
3. Effects of low-dose atorvastatin and rosuvastatin on plasma lipid profiles : a long-term, randomized, open-label study in patients with primary hypercholesterolemia. [J] . Mazza F, Stefanutti C, Di-Giacomo S, American journal of cardiovascular drugs: drugs, devices, and other interventions . 2008,第4期

机译：小剂量阿托伐他汀和瑞舒伐他汀对血浆脂质谱的影响：原发性高胆固醇血症患者的一项长期，随机，开放标签研究。
4. COMPARISON OF LIPID PROFILES OF HUMAN MEIBUM FROM DRY EYE PATIENTS: DRUG VS. PLACEBO TREATMENT USING ESI-QTOF AND MALDI-TOF/TOF-MS [C] . Kari B. Green-Church, Jiangzhong Chen, Nan M. Kleinholz, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：人类牡蛎脂质曲线与干眼患者的脂质谱比较：药物与利用ESI-QTOF和MALDI-TOF / TOF-MS的安慰剂处理
5. "I want a better life!" Examining juvenile drug treatment court participant characteristics: Is there a profile for success? [D] . Etheridge, Tianna D. 2013

机译：“我想要更好的生活！”检查青少年药物治疗法院参与者的特征：是否有成功的概况？
6. A Randomized Controlled Study to Compare the Effects of Rosuvastatin 5 mg and Atorvastatin 10 mg on the Plasma Lipid Profile in Japanese Patients with Hypercholesterolemia (ASTRO-2) [O] . Tsutomu Yamazaki, Masahiko Kurabayashi 2009

机译：一项随机对照研究比较了瑞舒伐他汀5 mg和阿托伐他汀10 mg对日本高胆固醇血症（ASTRO-2）患者血浆脂质谱的影响
7. A Randomized Controlled Study to Compare the Effects of Rosuvastatin 5mg and Atorvastatin10mg on the Plasma Lipid Profile in Japanese Patients with Hypercholesterolemia (ASTRO-2) [O] . Tsutomu Yamazaki, Masahiko Kurabayashi 2009

机译：一种随机对照研究，可比较日本高胆固醇血症患者血浆脂质曲线（Astro-2）的血浆脂质曲线的疗效

THE GENOTOXICITY PROFILE OF ATORVASTATIN, A NEW DRUG IN THE TREATMENT OF HYPERCHOLESTEROLEMIA

摘要

著录项

相似文献

相关主题

期刊订阅