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首页> 外文期刊>Mutation Research. Reviews in Mutation Research >Milk and dairy products in cancer prevention: focus on bovine lactoferrin
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Milk and dairy products in cancer prevention: focus on bovine lactoferrin

机译：牛奶和乳制品预防癌症：关注牛乳铁蛋白

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Milk and dairy products constitute an important part of the western style diet. A large number of epidemiological studies have been conducted to determine effects of consumption on cancer development but the data are largely equivocal, presumably reflecting the different included components. It has been proposed that whereas fats in general could promote tumor development, individual milk fats like conjugated linoleic acid could exert inhibitory effects. There is also considerable evidence that calcium in milk products protects against colon cancer, while promoting in the prostate through suppression of circulating levels of 1,25-dihydroxyvitamin D3. Whey protein may also be beneficial, as shown by both animal and human studies, and experimental data have demonstrated that the major component bovine lactoferrin (bLF), inhibits colon carcinogenesis in the post-initiation stage in male F344 rats treated with azoxymethane (AOM) without any overt toxicity. The incidence of adenocarcinomas in the groups receiving 2% and 0.2% bLF were thus 15% and 25%, respectively, in contrast to the 57.5% control value (P < 0.01 and P < 0.05, respectively). Results in other animal models have provided further indications that bLF might find application as a natural ingredient of milk with potential for chemoprevention of colon and other cancers.
机译：牛奶和乳制品构成西式饮食的重要组成部分。已经进行了大量的流行病学研究，以确定消费对癌症发展的影响，但数据在很大程度上是模棱两可的，大概反映了所包含的不同成分。已经提出，尽管脂肪通常可以促进肿瘤发展，但是诸如共轭亚油酸的单个乳脂肪可以发挥抑制作用。也有大量证据表明，奶制品中的钙可预防结肠癌，同时可通过抑制1,25-二羟基维生素D3的循环水平而促进前列腺癌的发展。正如动物和人体研究所表明的那样，乳清蛋白也可能是有益的，实验数据表明，主要成分牛乳铁蛋白（bLF）在用乙氧基甲烷（AOM）处理的雄性F344大鼠中，在启动后阶段抑制结肠癌的发生。没有任何明显的毒性。因此，接受2％bLF和0.2％bLF的组中腺癌的发生率分别为15％和25％，而对照值为57.5％（分别为P <0.01和P <0.05）。其他动物模型的结果进一步表明，bLF可能被发现是牛奶的天然成分，具有化学预防结肠癌和其他癌症的潜力。

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