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首页> 外文期刊>Mutation Research. Reviews in Mutation Research >A survey of EPA/OPP and open literature on selected pesticide chemicals III. Mutagenicity and carcinogenicity of benomyl and carbendazim [Review]
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A survey of EPA/OPP and open literature on selected pesticide chemicals III. Mutagenicity and carcinogenicity of benomyl and carbendazim [Review]

机译：EPA / OPP调查和有关选定农药化学物质的公开文献III。苯菌灵和多菌灵的致突变性和致癌性[综述]

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摘要

known aneuploidogens, benomyl and its metabolite, carbendazim (methyl 2-benzimidazole carbamate (MBC)), were selected for the third in a series of ongoing projects with selected pesticides. Mutagenicity and carcinogenicity data submitted to the US Environmental Protection Agency's (US EPA's) Office of Pesticide Programs (OPP) as part of the registration process are examined along with data from the open literature. Mutagenicity and carcinogenicity profiles are developed to provide a complete overview and to determine whether an association can be made between benomyl- and MBC-induced mouse liver tumors and aneuploidy. Since aneuploidogens are considered to indirectly affect DNA, the framework adopted by the Agency for evaluating any mode of action (MOA) for carcinogenesis is applied to the benomyl/MBC data.
机译：在一系列正在进行的与选定农药合作的项目中，第三项选择了已知的非整倍体原，苯菌灵及其代谢物多菌灵（2-苯并咪唑氨基甲酸甲酯（MBC））。作为注册过程的一部分，将提交给美国环境保护局（US EPA）农药计划办公室（OPP）的致突变性和致癌性数据与公开文献中的数据进行检查。开发了致突变性和致癌性概况，以提供完整的概述并确定是否可以在苯菌灵和MBC诱导的小鼠肝肿瘤与非整倍性之间建立关联。由于非整倍体原被认为会间接影响DNA，因此原子能机构采用的用于评估致癌作用的任何作用方式（MOA）的框架都适用于苯菌灵/ MBC数据。

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