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首页> 外文期刊>Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects >Biomarkers of genotoxicity of urban air pollution. Overview and descriptive data from a molecular epidemiology study on populations exposed to moderate-to-low levels of polycyclic aromatic hydrocarbons: the AULIS project.
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Biomarkers of genotoxicity of urban air pollution. Overview and descriptive data from a molecular epidemiology study on populations exposed to moderate-to-low levels of polycyclic aromatic hydrocarbons: the AULIS project.

机译：城市空气污染遗传毒性的生物标志物。分子流行病学研究的概述和描述性数据，涉及暴露于中低水平的多环芳烃的人口：AULIS项目。

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摘要

Epidemiologic studies indicate that prolonged exposure to high pollution levels is associated with increased risk of cancer, especially lung cancer. However, under conditions of moderate or low air pollution, epidemiologic evidence does not permit reliable conclusions. Biomarker-based population studies may serve as complementary tools providing a better understanding of the relative contribution of ambient atmospheric pollution to the overall genotoxic burden suffered by city dwellers. However, past efforts to apply biomarkers to studies of low levels exposure to urban air pollution have given inconclusive results, partly because of the absence of adequate data on personal exposure, covering a time-window which is appropriate for the biomarkers being examined, as well as a battery of biomarkers reflecting different stages of the carcinogenic process.In the present paper, the potential of biomarker-based population studies to aid the assessment of the genotoxic and carcinogenic effects of urban air pollution is reviewed by reference to the achievements and limitations of earlier reported studies. The design and methodology adopted in a recently completed large-scale population study, carried out in the context of the European Union Environment and Climate Programme, known by the short name of AULIS project, is discussed and descriptive statistics of the main findings of the project are presented. These findings indicate that for cohorts suffering moderate-to-low exposures to airborne particulate-bound polycyclic aromatic hydrocarbons (PAHs), no simple correlation with biomarkers of genotoxicity existed and suggest that additional factors made a significant contribution to the overall genotoxic burden.
机译：流行病学研究表明，长时间暴露于高污染水平与罹患癌症尤其是肺癌的风险增加有关。但是，在中等或低空气污染的条件下，流行病学证据不能得出可靠的结论。基于生物标记的人口研究可以作为补充工具，使人们更好地了解周围大气污染对城市居民总体遗传毒性负担的相对贡献。但是，过去将生物标志物应用于城市空气低浓度暴露研究的努力并未得出结论性的结果，部分原因是由于缺乏足够的个人暴露数据，该数据涵盖的时间窗口也适用于所研究的生物标志物本文以生物标志物为基础的人口研究在评估城市空气污染的遗传毒性和致癌作用方面的潜力进行了回顾，并参考了其成就和局限性。较早报道的研究。讨论了在最近完成的大规模人口研究中采用的设计和方法，该研究是在欧洲联盟环境与气候计划的背景下进行的，该计划被称为AULIS项目的简称，并对该项目的主要发现进行了描述性统计被提出。这些发现表明，对于中度至低暴露于空气中结合微粒的多环芳烃（PAHs）的队列，不存在与遗传毒性生物标志物的简单关联，并表明其他因素对总体遗传毒性负担做出了重大贡献。

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