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首页> 外文期刊>Molecular cancer therapeutics >Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death.
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Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death.

机译：具有获得性抗雌激素抗性的乳腺癌细胞对顺铂诱导的细胞死亡敏感。

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摘要

Antiestrogens are currently used for treating breast cancer patients who have estrogen receptor-positive tumors. However, patients with advanced disease will eventually develop resistance to the drugs. Therefore, compounds effective on antiestrogen-resistant tumors will be of great importance for future breast cancer treatment. In this study, we have investigated the effect of the chemotherapeutic compound cisplatin using a panel of antiestrogen-resistant breast cancer cell lines established from the human breast cancer cell line MCF-7. We show that the antiestrogen-resistant cells are significantly more sensitive to cisplatin-induced cell death than antiestrogen-sensitive MCF-7 cells and we show that cisplatin induces cell death by activating both the caspase and lysosomal death pathways. The antiestrogen-resistant cell lines express lower levels of antiapoptotic Bcl-2 protein compared with parental MCF-7 cells. Our data show that Bcl-2 can protect antiestrogen-resistant breast cancer cells from cisplatin-induced cell death, indicating that the reduced expression of Bcl-2 in the antiestrogen-resistant cells plays a role in sensitizing the cells to cisplatin treatment.
机译：抗雌激素目前用于治疗患有雌激素受体阳性肿瘤的乳腺癌患者。但是，患有晚期疾病的患者最终将对药物产生耐药性。因此，对抗雌激素抗性肿瘤有效的化合物对于将来的乳腺癌治疗将具有重要意义。在这项研究中，我们使用从人乳腺癌细胞系MCF-7建立的一组抗雌激素耐药乳腺癌细胞系，研究了化学治疗性化合物顺铂的作用。我们显示抗雌激素抵抗细胞比对雌激素敏感的MCF-7细胞对顺铂诱导的细胞死亡明显更敏感，并且我们显示顺铂通过激活caspase和溶酶体死亡途径来诱导细胞死亡。与亲本MCF-7细胞相比，抗雌激素的细胞系表达较低水平的抗凋亡Bcl-2蛋白。我们的数据表明，Bcl-2可以保护抗雌激素的乳腺癌细胞免受顺铂诱导的细胞死亡，表明抗雌激素的细胞中Bcl-2表达的降低在使细胞对顺铂治疗敏感中起作用。

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