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首页> 外文期刊>Cancer: A Journal of the American Cancer Society >Does skin cancer screening save lives?: An observational study comparing trends in melanoma mortality in regions with and without screening
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Does skin cancer screening save lives?: An observational study comparing trends in melanoma mortality in regions with and without screening

机译：皮肤癌筛查是否可以挽救生命？：一项观察性研究，比较有无筛查区域的黑色素瘤死亡率趋势

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Background: From July 1, 2003 to June 30, 2004, a population-based skin cancer screening project was conducted in Schleswig-Holstein, Germany. In total, 360,288 individuals aged ≥20 years were screened by means of a whole-body examination. In this report, the authors compare trends in melanoma mortality in Schleswig-Holstein with those in all adjacent regions, none of which had population-based skin cancer screening. Methods: Trends in melanoma mortality rates for Schleswig-Holstein and the adjacent regions (Denmark and the German federal states of Mecklenburg-Vorpommern, Hamburg, and Lower Saxony) and in Germany excluding Schleswig-Holstein were compared. Log-linear regression was used to assess mortality trends. Results: In Schleswig-Holstein during the pre skin cancer screening period (1998-1999), the age-standardized melanoma mortality rate (World standard population) was 1.9 per 100,000 for men and 1.4 per 100,000 for women. Melanoma mortality declined by 47% to 1.0 per 100,000 men and by 49% to 0.7 per 100,000 women by 2008/2009. The annual percentage change in the most recent 10-year period (2000-2009) was -7.5% (95% confidence interval, -14.0, -0.5) for men and -7.1% (95% confidence interval, -10.5, -2.9) for women. In each of the 4 adjacent regions and in the rest of Germany, mortality rates were stable, and the decline in Schleswig-Holstein was significantly different from the changes observed in all of the other areas studied. Conclusions: The current data represent strong evidence, but not absolute proof, that the skin cancer screening program produced a reduction in melanoma mortality in Schleswig-Holstein. Cancer 2012.
机译：背景：从2003年7月1日至2004年6月30日，在德国石勒苏益格-荷尔斯泰因州开展了基于人群的皮肤癌筛查项目。通过全身检查，共筛查了360,288名≥20岁的人。在本报告中，作者比较了石勒苏益格-荷尔斯泰因州和所有邻近地区的黑素瘤死亡率趋势，这些地区均未进行基于人群的皮肤癌筛查。方法：比较石勒苏益格-荷尔斯泰因州和邻近地区（丹麦和梅克伦堡-前波莫瑞州，汉堡和下萨克森州的联邦州）以及德国（石勒苏益格-荷尔斯泰因州除外）的黑色素瘤死亡率趋势。对数线性回归用于评估死亡率趋势。结果：在石勒苏益格-荷尔斯泰因州（Schleswig-Holstein），皮肤癌前筛查阶段（1998-1999年），年龄标准化的黑素瘤死亡率（世界标准人群）男性为100,000人中的1.9人，女性为100,000人中的1.4人。到2008/2009年，黑色素瘤死亡率下降了47％，降至每100,000名男性中的1.0％，下降了49％，降至每100,000名女性中0.7的女性。最近十年（2000-2009）的年度百分比变化为男性-7.5％（95％置信区间，-14.0，-0.5）和-7.1％（95％置信区间，-10.5，-2.9） ） 女用。在四个相邻地区的每个地区以及德国其他地区，死亡率保持稳定，石勒苏益格-荷尔斯泰因州的下降与所有其他研究区域的变化均存在显着差异。结论：目前的数据是有力的证据，但不是绝对的证据，表明皮肤癌筛查程序可降低石勒苏益格-荷尔斯泰因州的黑素瘤死亡率。癌症2012。

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