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首页> 外文期刊>Molecular cell >Nitric Oxide Sensing in Plants Is Mediated by Proteolytic Control of Group VII ERF Transcription Factors
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Nitric Oxide Sensing in Plants Is Mediated by Proteolytic Control of Group VII ERF Transcription Factors

机译:植物中一氧化氮的感应是通过蛋白水解控制VII族ERF转录因子介导的。

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摘要

Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions andstress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). Weshow that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germinationand crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants.
机译:一氧化氮(NO)是原核生物和真核生物中重要的信号传导化合物。在植物中,NO调节关键的发育过渡和胁迫响应。在这里,我们确定了一种NO感应的机制,该机制可根据植物特异性转录调节因子,第七族乙烯响应因子(ERFs)的定向降解,协调整个发育过程中的响应。我们表明靶向蛋白水解的N端规则途径将这些蛋白质靶向破坏存在的NO,并且我们将它们确立为各种NO调控过程(包括种子发芽,气孔关闭和下胚轴伸长)的关键调控因子。此外,我们定义了通过脱落酸(ABA)信号通过ERF调节ABSCISIC ACID INSENSITIVE5(ABI5)的表达来控制NO萌发和串扰的分子机制。我们的工作演示了如何通过直接调节转录因子的稳定性将NO感测整合到多个生理过程中,并将VII组ERF识别为感知植物中气态信号的中心枢纽。

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