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首页> 外文期刊>Molecular cancer therapeutics >miRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling.
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miRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling.

机译：miRNA-29b通过调节上皮-间质转化信号抑制前列腺癌的转移。

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Prostate cancer remains the second leading cause of cancer deaths among American men. Early diagnosis increases survival rate in patients; however, treatments for advanced disease are limited to hormone ablation techniques and palliative care. Thus, new methods of treatment are necessary for inhibiting prostate cancer disease progression. Here, we have shown that miRNA-29b (miR-29b) expression was lower in prostate cancer cells (PC3 and LNCaP) as compared with immortalized prostate epithelial cells. Between these two prostate cancer cell lines, metastatic prostate cancer PC3 cells displayed lower expression of miR-29b. We also observed a significant downregulation of miR-29b expression in human prostate cancer tissues as compared with patient-matched nontumor tissues. PC3 cells ectopically expressing miR-29b inhibited wound healing, invasiveness, and failed to colonize in the lungs and liver of severe combined immunodeficient mice after intravenous injection, while PC3 cells expressing a control miRNA displayed metastasis. Epithelial cell marker E-cadherin expression was enhanced miR-29b transfected in prostate cancer cells as compared with cells expressing control miRNA. On the other hand, N-cadherin, Twist, and Snail expression was downregulated in PC3 cells expressing miR-29b. Together these results suggested that miR-29b acts as an antimetastatic miRNA for prostate cancer cells at multiple steps in a metastatic cascade. Therefore, miR-29b could be a potentially new attractive target for therapeutic intervention in prostate cancer. Mol Cancer Ther; 11(5); 1166-73. ?2012 AACR.
机译：前列腺癌仍然是美国男性中癌症死亡的第二大主要原因。早期诊断可提高患者的生存率;但是，晚期疾病的治疗仅限于激素消融技术和姑息治疗。因此，新的治疗方法对于抑制前列腺癌疾病的发展是必要的。在这里，我们显示了与永生化前列腺上皮细胞相比，前列腺癌细胞（PC3和LNCaP）中的miRNA-29b（miR-29b）表达较低。在这两种前列腺癌细胞系之间，转移性前列腺癌PC3细胞显示出较低的miR-29b表达。我们还观察到与患者匹配的非肿瘤组织相比，miR-29b在人前列腺癌组织中的表达显着下调。异位表达miR-29b的PC3细胞抑制伤口愈合，侵袭性，并且在静脉注射后不能在严重的免疫缺陷合并症小鼠的肺和肝脏中定植，而表达对照miRNA的PC3细胞则表现出转移。与表达对照miRNA的细胞相比，在前列腺癌细胞中转染的miR-29b增强了上皮细胞标记E-钙粘着蛋白的表达。另一方面，在表达miR-29b的PC3细胞中，N-钙黏着蛋白，Twist和Snail表达被下调。这些结果共同表明，miR-29b在转移级联的多个步骤中充当前列腺癌细胞的抗转移miRNA。因此，miR-29b可能是前列腺癌治疗干预的潜在新靶标。分子癌疗法; 11（5）; 1166-73。 2012年AACR。

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