Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

Perkins G; Diffley JF

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Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

机译：Cdc6p依赖核苷酸的复制前复合物装配体，Cdc6p是真核和原核钳装载器的同源物。

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Expression of the Cdc6 protein (Cdc6p) is essential for formation of prereplicative complexes at budding yeast replication origins. Analysis of mutations in the conserved nucleoside triphosphate (NTP)-binding site of Cdc6p described here suggests that NTPs are required both for the productive interaction of Cdc6p with replication origins during G1 and the quantitative loading of the Mcm2-7 family of proteins onto chromatin. We show that Cdc6p exhibits significant sequence similarity to subunits of eukaryotic and prokaryotic clamp-loaders, which load ring-shaped DNA polymerase processivity factors onto DNA in an analogous reaction. Similarities in both sequence and mechanism suggest that Cdc6p and the clamp-loaders are members of a superfamily of nucleotide-dependent loading factors.

机译：Cdc6蛋白（Cdc6p）的表达对于在萌芽的酵母复制起点形成复制前复合物至关重要。在此描述的Cdc6p的保守三磷酸核苷（NTP）结合位点的突变分析表明，NTP是Cdc6p与G1期间复制起点的生产性相互作用以及Mcm2-7家族蛋白在染色质上定量加载所必需的。我们表明，Cdc6p展示出显着的序列相似性，以真核和原核钳装载器的亚基，在类似的反应中将环状DNA聚合酶的合成因子装载到DNA上。序列和机制上的相似性表明，Cdc6p和钳位加载子是核苷酸依赖性加载因子超家族的成员。

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《Molecular cell》 |1998年第1期|共10页
作者
Perkins G; Diffley JF;
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正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
Cell Cycle Proteins; DNA Replication; DNA; Fungal; Fungal Proteins; Saccharomyces cerevisiae; 细胞周期蛋白质类; DNA复制; DNA; 真菌; 真菌蛋白质类; 酵母菌; 酿酒;

机译：Cell Cycle Proteins;DNA Replication;DNA;Fungal;Fungal Proteins;Saccharomyces cerevisiae;细胞周期蛋白质类;DNA复制;DNA;真菌;真菌蛋白质类;酵母菌;酿酒;

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1. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. [J] . Perkins G, Diffley JF Molecular cell . 1998,第1期

机译：Cdc6p依赖核苷酸的复制前复合物装配体，Cdc6p是真核和原核钳装载器的同源物。
2. Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. [J] . Merritt EA, Arakaki TL, Gillespie JR, Journal of Molecular Biology . 2010,第2期

机译：锥虫组氨酸-tRNA合成酶的晶体结构阐明了真核和原核同源物之间的差异。
3. Prokaryotic Homologs of the Eukaryotic 3-Hydroxyanthranilate 3,4-Dioxygenase and 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase in the 2-Nitrobenzoate Degradation Pathway of Pseudomonas fluorescens Strain KU-7 [J] . Takamichi Muraki, Masami Taki, Yoshie Hasegawa, Applied and Environmental Microbiology . 2003,第3期

机译：荧光假单胞菌菌株KU-7的2-硝基苯甲酸酯降解途径中的真核生物3-羟基邻氨基苯甲酸3,4-双加氧酶和2-氨基-3-羧粘康酸酯-6-半醛脱羧酶的原核同源物
4. STRUCTURAL COMPARISONS BETWEEN EUKARYOTIC AND PROKARYOTIC PSII COMPLEXES [C] . Jon Nield, James Barber International Congress of Photosynthesis . 2005

机译：真核生物和原核PSII复合物之间的结构比较
5. Understanding the Intercations Between Prokaryotic and Eukaryotic Cells with Nanorough Medical Implants [D] . Ghannadian, Paria. 2020

机译：了解用纳尔伯勒医疗植入物的原核和真核细胞之间的相互作用
6. Prokaryotic Homologs of the Eukaryotic DNA-End-Binding Protein Ku Novel Domains in the Ku Protein and Prediction of a Prokaryotic Double-Strand Break Repair System [O] . L. Aravind, Eugene V. Koonin 2001

机译：真核DNA末端结合蛋白Ku的原核同系物Ku蛋白中的新结构域和原核双链断裂修复系统的预测。
7. Prokaryotic Homologs of the Eukaryotic DNA-End-Binding Protein Ku, Novel Domains in the Ku Protein and Prediction of a Prokaryotic Double-Strand Break Repair System [O] . Aravind, L., Koonin, Eugene V. 2001

机译：真核DNA末端结合蛋白Ku的原核同系物，Ku蛋白中的新结构域和原核双链断裂修复系统的预测。

Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

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